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Gene Review

ACTR1A  -  ARP1 actin-related protein 1 homolog A,...

Homo sapiens

Synonyms: ARP1, Actin-RPV, Alpha-centractin, CTRN1, Centractin, ...
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Disease relevance of ACTR1A


High impact information on ACTR1A

  • Morphological and biochemical criteria show that centractin is associated with centrosomes [5].
  • Upon nuclear envelope breakdown, large cytoplasmic aggregates of green fluorescent protein (GFP)-tagged NuMA stream poleward along spindle fibers in association with the actin-related protein 1 (Arp1) protein of the dynactin complex and cytoplasmic dynein [6].
  • To investigate potential functions of the protein, we used transient transfections to overexpress centractin in mammalian cells [7].
  • We examined the transfected cells for evidence of specific associations of the novel centractin filaments with cellular organelles or cytoskeletal proteins [7].
  • The primary amino acid sequence of Act3p is most similar to canine and human alpha-centractin (73% similarity/54% identity) [8].

Biological context of ACTR1A


Anatomical context of ACTR1A


Physical interactions of ACTR1A


Other interactions of ACTR1A

  • The TRiC (TCP1 Ring Complex) chaperonin complex participates in the functional folding of actin, centractin, alpha-, beta-, gamma-tubulin, and phytochrome [16].

Analytical, diagnostic and therapeutic context of ACTR1A


  1. Transcriptional activation by the orphan nuclear receptor ARP-1. Malik, S., Karathanasis, S. Nucleic Acids Res. (1995) [Pubmed]
  2. PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Wang, W., Hayashi, J., Serrero, G. Clin. Cancer Res. (2006) [Pubmed]
  3. Structural but not functional conservation of an immune molecule: a tachylectin-like gene in Hydractinia. Mali, B., Soza-Ried, J., Frohme, M., Frank, U. Dev. Comp. Immunol. (2006) [Pubmed]
  4. Aberrant expression of centractin and capping proteins, integral constituents of the dynactin complex, in fetal down syndrome brain. Gulesserian, T., Kim, S.H., Fountoulakis, M., Lubec, G. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  5. Centractin is an actin homologue associated with the centrosome. Clark, S.W., Meyer, D.I. Nature (1992) [Pubmed]
  6. Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. Merdes, A., Heald, R., Samejima, K., Earnshaw, W.C., Cleveland, D.W. J. Cell Biol. (2000) [Pubmed]
  7. Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. Holleran, E.A., Tokito, M.K., Karki, S., Holzbaur, E.L. J. Cell Biol. (1996) [Pubmed]
  8. ACT3: a putative centractin homologue in S. cerevisiae is required for proper orientation of the mitotic spindle. Clark, S.W., Meyer, D.I. J. Cell Biol. (1994) [Pubmed]
  9. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. Clark, S.W., Staub, O., Clark, I.B., Holzbaur, E.L., Paschal, B.M., Vallee, R.B., Meyer, D.I. Mol. Biol. Cell (1994) [Pubmed]
  10. Self-regulated polymerization of the actin-related protein Arp1. Bingham, J.B., Schroer, T.A. Curr. Biol. (1999) [Pubmed]
  11. ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis. Fouquet, J., Kann, M., Souès, S., Melki, R. J. Cell. Sci. (2000) [Pubmed]
  12. Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase. Clark, I.B., Meyer, D.I. J. Cell. Sci. (1999) [Pubmed]
  13. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Waterman-Storer, C.M., Karki, S., Holzbaur, E.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice. Rottman, J.N., Gordon, J.I. J. Biol. Chem. (1993) [Pubmed]
  15. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. Karki, S., Tokito, M.K., Holzbaur, E.L. J. Biol. Chem. (2000) [Pubmed]
  16. Functional role of a consensus peptide which is common to alpha-, beta-, and gamma-tubulin, to actin and centractin, to phytochrome A, and to the TCP1 alpha chaperonin protein. Burns, R.G., Surridge, C.D. FEBS Lett. (1994) [Pubmed]
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