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Gene Review:

pr-set7 - CG3307 gene product from transcript CG3307-RB

Drosophila melanogaster

Synonyms: CG3307, Dmel\CG3307, Histone-lysine N-methyltransferase pr-set7, KMT5A, Lysine N-methyltransferase 5A, ...

Karachentsev, D. et al., Sakaguchi, A. et al., Nishioka, K. et al.

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High impact information on pr-set7

These data show that PR-Set7-dependent methylation is essential for the process of mitosis [1].
We isolated a null mutation in Drosophila PR-Set7 that suppresses position effect variegation, indicating that PR-Set7 indeed functions in silencing general gene expression [1].
The histone methyl transferase PR-Set7 mediates histone H4 Lys 20 methylation, a mark of constitutive and facultative heterochromatin [1].
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin [2].
Our results show that in PR-Set7 mutants, the DNA damage checkpoint is activated [3].

Biological context of pr-set7

The methylation mark is highly stable and is maintained even in the absence of PR-Set7 protein [1].
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis [1].
PR-Set7 also showed a defect in chromosome condensation that was enhanced in the double mutant [3].
PR-Set7 is a histone methyltransferase that specifically monomethylates histone H4 lysine 20 (K20) and is essential for cell proliferation [3].

References

PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Karachentsev, D., Sarma, K., Reinberg, D., Steward, R. Genes Dev. (2005) [Pubmed]
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Nishioka, K., Rice, J.C., Sarma, K., Erdjument-Bromage, H., Werner, J., Wang, Y., Chuikov, S., Valenzuela, P., Tempst, P., Steward, R., Lis, J.T., Allis, C.D., Reinberg, D. Mol. Cell (2002) [Pubmed]
Aberrant monomethylation of histone H4 lysine 20 activates the DNA damage checkpoint in Drosophila melanogaster. Sakaguchi, A., Steward, R. J. Cell Biol. (2007) [Pubmed]

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