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Gene Review

MEOX1  -  mesenchyme homeobox 1

Homo sapiens

Synonyms: Homeobox protein MOX-1, KFS2, MOX1, Mesenchyme homeobox 1
 
 
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High impact information on MEOX1

  • No evidence for mutation was found in the coding sequence, making it unlikely that MOX1 is the BRCA1 gene [1].
  • Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture [1].
  • Multiple overlapping cDNAs of human MOX1 were identified using both a cosmid and a P1 genomic clone containing the microsatellite markers D17S750 and D17S858 which map within the BRCA1 region defined by D17S776 and D17S78 [1].
  • This gene is the human homologue of the mouse Mox1 gene previously localized to a syntenic region of mouse chromosome 11 [1].
  • A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population [2].
 

Biological context of MEOX1

  • MOX-1 was expressed in a pattern similar to MSX early in gestation but then was restricted exclusively to follicular cells in the innermost layer of the outer root sheath by 21 weeks of development [3].

References

  1. Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. Futreal, P.A., Cochran, C., Rosenthal, J., Miki, Y., Swenson, J., Hobbs, M., Bennett, L.M., Haugen-Strano, A., Marks, J., Barrett, J.C. Hum. Mol. Genet. (1994) [Pubmed]
  2. A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. Staehling-Hampton, K., Proll, S., Paeper, B.W., Zhao, L., Charmley, P., Brown, A., Gardner, J.C., Galas, D., Schatzman, R.C., Beighton, P., Papapoulos, S., Hamersma, H., Brunkow, M.E. Am. J. Med. Genet. (2002) [Pubmed]
  3. The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin. Stelnicki, E.J., Kömüves, L.G., Holmes, D., Clavin, W., Harrison, M.R., Adzick, N.S., Largman, C. Differentiation (1997) [Pubmed]
 
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