Disease relevance of C15

• Surfactin C14, surfactin C15, and iturin C15 are lipopeptides purified from Bacillus subtilis (S499 strain) [1].

High impact information on C15

• We show that C15 expression requires both dpp and zen, thus forming a genetic feed-forward loop [2].
• C15/Al also act indirectly to repress ap in ta V, i.e., in surrounding cells [3].
• C15 is expressed in the same cells as al and, together, C15 and Al appear to directly repress B [3].
• Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15 [3].
• In wild-type labial discs, clawless, one of the two homeobox genes expressed in distal cells receiving maximum (Decapentaplegic+Wingless) signaling activity in leg and antennal discs, is specifically repressed by proboscipedia [4].

Associations of C15 with chemical compounds

• This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family [5].
• At 100 ppm, surfactin C14 and C15 showed respectively 85.4 and 92.6% adults mortality after one-day exposure [1].

References