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Gene Review

C15  -  CG7937 gene product from transcript CG7937-RA

Drosophila melanogaster

Synonyms: 311, 93Bal, CG7937, Cll, Dmel\CG7937, ...
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Disease relevance of C15


High impact information on C15

  • We show that C15 expression requires both dpp and zen, thus forming a genetic feed-forward loop [2].
  • C15/Al also act indirectly to repress ap in ta V, i.e., in surrounding cells [3].
  • C15 is expressed in the same cells as al and, together, C15 and Al appear to directly repress B [3].
  • Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15 [3].
  • In wild-type labial discs, clawless, one of the two homeobox genes expressed in distal cells receiving maximum (Decapentaplegic+Wingless) signaling activity in leg and antennal discs, is specifically repressed by proboscipedia [4].

Associations of C15 with chemical compounds

  • This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family [5].
  • At 100 ppm, surfactin C14 and C15 showed respectively 85.4 and 92.6% adults mortality after one-day exposure [1].


  1. Insecticide activity of surfactins and iturins from a biopesticide Bacillus subtilis Cohn (S499 strain). Assié, L.K., Deleu, M., Arnaud, L., Paquot, M., Thonart, P., Gaspar, C.h., Haubruge, E. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2002) [Pubmed]
  2. Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. Lin, M.C., Park, J., Kirov, N., Rushlow, C. Development (2006) [Pubmed]
  3. Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15. Campbell, G. Dev. Biol. (2005) [Pubmed]
  4. Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes. Yasunaga, K., Saigo, K., Kojima, T. Mech. Dev. (2006) [Pubmed]
  5. A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes. Dear, T.N., Rabbitts, T.H. Gene (1994) [Pubmed]
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