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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

lmd  -  lame duck

Drosophila melanogaster

Synonyms: CG4677, Dmel\CG4677, LMD, Lmd, anon-EST:CL2d4, ...
 
 
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High impact information on lmd

  • These findings underscore the importance of regulated Lmd protein activity in maintaining proper activation of downstream target genes, such as Mef2, within fusion-competent myoblasts [1].
  • Lame duck (Lmd), a member of the Gli superfamily of transcription factors, is essential for the specification and differentiation of fusion-competent myoblasts [1].
  • Activation of the Lmd protein is also tempered by posttranslational modifications of the protein that do not detectably change its subcellular localization [1].
  • myoblasts incompetent encodes a zinc finger transcription factor required to specify fusion-competent myoblasts in Drosophila [2].
  • Embryos that lack lmd function show a loss of expression of two key differentiation and fusion genes, Mef2 and sticks-and-stones, in fusion-competent myoblasts and are completely devoid of multinucleate muscle fibers [3].
 

Biological context of lmd

  • Results from an independent molecular screen for binding factors to a myoblast-specific Mef2 enhancer further demonstrate that Lmd is a direct transcriptional regulator of Mef2 in fusion-competent myoblasts [3].
  • Thus myoblasts incompetent appears to function specifically in the general pathway of myogenesis to control the differentiation of fusion-competent myoblasts [2].
 

Anatomical context of lmd

  • We show that a newly identified gene, lame duck (lmd), has an essential regulatory role in the specification and function of fusion-competent myoblasts [3].
 

Associations of lmd with chemical compounds

  • RT-PCR analysis revealed that the expressions of fusion-competent myoblast-specific genes lmd, sns, and del were induced in Schneider cells upon treatment with NCS or HU, whereas expressions of three founder cell-specific genes, duf, ants, and rols, were undetectable [4].

References

 
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