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Gene Review

SMURF2  -  SMAD specific E3 ubiquitin protein ligase 2

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High impact information on SMURF2

  • Overall, Aza-treated ACs represent a novel model for the study of mechanisms that regulate maturational potential of articular cartilage, with the data suggesting that maturation of these cells may be due to up-regulation of Smad1 and 5 coupled with a Smurf2-dependent degradation of Smad2 and 3 and loss of TGF-beta signaling [1].
  • Suggesting that Aza-induction of Smurf2 may be responsible for the loss of Smad2 and 3 protein via this pathway, immunoprecipitation and metabolic labeling experiments confirmed that Aza accelerated the ubiquitination and degradation of these targets [1].


  1. 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. Zuscik, M.J., Baden, J.F., Wu, Q., Sheu, T.J., Schwarz, E.M., Drissi, H., O'Keefe, R.J., Puzas, J.E., Rosier, R.N. J. Cell. Biochem. (2004) [Pubmed]
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