Gene Review:
SMURF2 - SMAD specific E3 ubiquitin protein ligase 2
Homo sapiens
Synonyms:
E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, hSMURF2
- High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma. Fukuchi, M., Fukai, Y., Masuda, N., Miyazaki, T., Nakajima, M., Sohda, M., Manda, R., Tsukada, K., Kato, H., Kuwano, H. Cancer Res. (2002)
- The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. Subramaniam, V., Li, H., Wong, M., Kitching, R., Attisano, L., Wrana, J., Zubovits, J., Burger, A.M., Seth, A. Br. J. Cancer (2003)
- Abnormal expression of Smurf2 during the process of rat liver fibrosis. Cai, Y., Shen, X.Z., Zhou, C.H., Wang, J.Y. Chinese journal of digestive diseases. (2006)
- Smurf2 up-regulation activates telomere-dependent senescence. Zhang, H., Cohen, S.N. Genes Dev. (2004)
- Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Ogunjimi, A.A., Briant, D.J., Pece-Barbara, N., Le Roy, C., Di Guglielmo, G.M., Kavsak, P., Rasmussen, R.K., Seet, B.T., Sicheri, F., Wrana, J.L. Mol. Cell (2005)
- TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Bonni, S., Wang, H.R., Causing, C.G., Kavsak, P., Stroschein, S.L., Luo, K., Wrana, J.L. Nat. Cell Biol. (2001)
- An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. Chong, P.A., Lin, H., Wrana, J.L., Forman-Kay, J.D. J. Biol. Chem. (2006)
- Smad7-induced beta-catenin degradation alters epidermal appendage development. Han, G., Li, A.G., Liang, Y.Y., Owens, P., He, W., Lu, S., Yoshimatsu, Y., Wang, D., Ten Dijke, P., Lin, X., Wang, X.J. Dev. Cell (2006)
- Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Kavsak, P., Rasmussen, R.K., Causing, C.G., Bonni, S., Zhu, H., Thomsen, G.H., Wrana, J.L. Mol. Cell (2000)
- Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta. Ohashi, N., Yamamoto, T., Uchida, C., Togawa, A., Fukasawa, H., Fujigaki, Y., Suzuki, S., Kitagawa, K., Hattori, T., Oda, T., Hayashi, H., Hishida, A., Kitagawa, M. FEBS Lett. (2005)
- Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Zhang, Y., Chang, C., Gehling, D.J., Hemmati-Brivanlou, A., Derynck, R. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. Lin, X., Liang, M., Feng, X.H. J. Biol. Chem. (2000)
- An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. Li, H., Seth, A. Oncogene (2004)
- Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Di Guglielmo, G.M., Le Roy, C., Goodfellow, A.F., Wrana, J.L. Nat. Cell Biol. (2003)