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Gene Review

msi  -  musashi

Drosophila melanogaster

Synonyms: CG5099, DMSIDNA, Dmel\CG5099, MSI, Msi, ...
 
 
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High impact information on msi

  • The msi putative RNA-binding protein is localized to the nucleus and appears to be expressed in all cells in each sensillum and predominantly in neurons during embryogenesis [1].
  • Using DNA radiolabelling in human tissue implanted into athymic nude mice, a population of label-retaining cells were shown to be enriched for the putative stem cell markers p21(CIP1) and Msi-1, the human homolog of Drosophila Musashi [2].
  • An enhancer trap in the ascidian Ciona intestinalis identifies enhancers of its Musashi orthologous gene [3].
  • Like other Musashi family members, MSI-1 is expressed specifically in neural cells, including male-specific neurones required for turning and vulva location [4].
  • Musashi and seven in absentia downregulate Tramtrack through distinct mechanisms in Drosophila eye development [5].
 

Biological context of msi

  • In addition, we utilized the flexibility of MovingTargets by relaxing the biological constraints to identify and validate miRNAs targeting tramtrack, a gene also known to be subject to translational control dependent on the RNA binding protein Musashi [6].

References

  1. Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development. Nakamura, M., Okano, H., Blendy, J.A., Montell, C. Neuron (1994) [Pubmed]
  2. A putative human breast stem cell population is enriched for steroid receptor-positive cells. Clarke, R.B., Spence, K., Anderson, E., Howell, A., Okano, H., Potten, C.S. Dev. Biol. (2005) [Pubmed]
  3. An enhancer trap in the ascidian Ciona intestinalis identifies enhancers of its Musashi orthologous gene. Awazu, S., Sasaki, A., Matsuoka, T., Satoh, N., Sasakura, Y. Dev. Biol. (2004) [Pubmed]
  4. MSI-1, a neural RNA-binding protein, is involved in male mating behaviour in Caenorhabditis elegans. Yoda, A., Sawa, H., Okano, H. Genes Cells (2000) [Pubmed]
  5. Musashi and seven in absentia downregulate Tramtrack through distinct mechanisms in Drosophila eye development. Hirota, Y., Okabe, M., Imai, T., Kurusu, M., Yamamoto, A., Miyao, S., Nakamura, M., Sawamoto, K., Okano, H. Mech. Dev. (1999) [Pubmed]
  6. Prediction and verification of microRNA targets by MovingTargets, a highly adaptable prediction method. Burgler, C., Macdonald, P.M. BMC Genomics (2005) [Pubmed]
 
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