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Gene Review

Nrg2  -  neuregulin 2

Rattus norvegicus

Synonyms: NTAK_alpha2a, Ntak, Pro-NRG2, Pro-neuregulin-2, membrane-bound isoform
 
 
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High impact information on Nrg2

 

Anatomical context of Nrg2

  • Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons [3].
  • We also show that unique Nrg-2 isoforms are differentially distributed between spinal cord and skeletal muscle, the tissues that harbor the cellular components of the neuromuscular synapse [4].
 

Other interactions of Nrg2

  • Here we determined in the I/I and III/III rats the gamma-secretase cleavage activity toward the three APP superfamily members, p75 neurotrophin receptor, ErbB4, and neuregulin-2, and found that the cleavage of only a subset of the substrates was changed [5].
 

Analytical, diagnostic and therapeutic context of Nrg2

  • Northern blot and in situ hybridization analysis of adult rat tissues indicate that expression of neuregulin-2 is highest in the cerebellum, and the expression pattern is different from that of neuregulins [1].

References

  1. Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Chang, H., Riese, D.J., Gilbert, W., Stern, D.F., McMahan, U.J. Nature (1997) [Pubmed]
  2. Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4. Rimer, M., Prieto, A.L., Weber, J.L., Colasante, C., Ponomareva, O., Fromm, L., Schwab, M.H., Lai, C., Burden, S.J. Mol. Cell. Neurosci. (2004) [Pubmed]
  3. Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons. Longart, M., Liu, Y., Karavanova, I., Buonanno, A. J. Comp. Neurol. (2004) [Pubmed]
  4. Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing. Ponomareva, O.N., Ma, H., Dakour, R., Raabe, T.D., Lai, C., Rimer, M. Neuroscience (2005) [Pubmed]
  5. Reduced Aph-1b expression causes tissue- and substrate-specific changes in gamma-secretase activity in rats with a complex phenotype. Coolen, M.W., van Loo, K.M., van Bakel, N.N., Ellenbroek, B.A., Cools, A.R., Martens, G.J. FASEB J. (2006) [Pubmed]
 
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