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Gene Review

Taf2  -  TBP-associated factor 2

Drosophila melanogaster

Synonyms: CG6711, Dmel\CG6711, TAF, TAF(II)150, TAF150, ...
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High impact information on Taf2

  • Interestingly, TAFII150 enhances Sp1 activation even though this subunit does not bind directly to Sp1 [1].
  • The deduced primary amino acid sequence of dTAFII150 reveals a striking similarity to the essential yeast gene, TSM-1 [2].
  • The data demonstrate that at least one of the TAFs is a sequence-specific DNA binding protein and that dTAFII150 together with TBP are responsible for TFIID interactions with an extended region of the core promoter [2].
  • Surprisingly, DNA binding studies indicate that purified recombinant dTAFII150 binds specifically to DNA sequences overlapping the start site of transcription [2].
  • Activator-dependent reinitiation of transcription, obviating the slow assembly of the TFIID-TFIIA complex on a promoter, may be especially crucial for genes requiring a fast response to inducers [3].

Biological context of Taf2

  • The heat shock genes provide an example for transcriptional regulation at a later step: in nuclei TFIID can be detected at the TATA box prior to heat induction [3].
  • Well-documented transcription activation mechanisms, such as the recruitment of TFIID and TFIIB, control the early phases of preinitiation complex formation [3].
  • TFIIA-TAF regulatory interplay: NMR evidence for overlapping binding sites on TBP [4].

Physical interactions of Taf2

  • Here we demonstrate that Drosophila TAF1 protein isoforms TAF1-2 and TAF1-4 directly bind DNA independently of TAF2 [5].


  1. Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators. Chen, J.L., Attardi, L.D., Verrijzer, C.P., Yokomori, K., Tjian, R. Cell (1994) [Pubmed]
  2. Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA. Verrijzer, C.P., Yokomori, K., Chen, J.L., Tjian, R. Science (1994) [Pubmed]
  3. Heat shock factor increases the reinitiation rate from potentiated chromatin templates. Sandaltzopoulos, R., Becker, P.B. Mol. Cell. Biol. (1998) [Pubmed]
  4. TFIIA-TAF regulatory interplay: NMR evidence for overlapping binding sites on TBP. Bagby, S., Mal, T.K., Liu, D., Raddatz, E., Nakatani, Y., Ikura, M. FEBS Lett. (2000) [Pubmed]
  5. DNA Binding Properties of TAF1 Isoforms with Two AT-hooks. Metcalf, C.E., Wassarman, D.A. J. Biol. Chem. (2006) [Pubmed]
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