Gene Review:
Adh - Alcohol dehydrogenase
Drosophila melanogaster
Synonyms:
ADH, Adh3, BG:DS01486.8, CG32954, CG3481, ...
- Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein. Benyajati, C., Place, A.R., Powers, D.A., Sofer, W. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Alcohol dehydrogenase in Drosophila: isolation and characterization of messenger RNA and cDNA clone. Benyajati, C., Wang, N., Reddy, A., Weinberg, E., Sofer, W. Nucleic Acids Res. (1980)
- Polymorphism at the Adh and alpha Gpdh loci in Drosophila melanogaster: effects of rearing temperature on developmental rate, body weight, and some biochemical parameters. Oudman, L., Van Delden, W., Kamping, A., Bijlsma, R. Heredity (1991)
- Alcohol and polyol dehydrogenases are both divided into two protein types, and structural properties cross-relate the different enzyme activities within each type. Jörnvall, H., Persson, M., Jeffery, J. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Enoyl-acyl-carrier-protein reductase and Mycobacterium tuberculosis InhA do not conserve the Tyr-Xaa-Xaa-Xaa-Lys motif in mammalian 11 beta- and 17 beta-hydroxysteroid dehydrogenases and Drosophila alcohol dehydrogenase. Baker, M.E. Biochem. J. (1995)
- Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences. Pal-Bhadra, M., Bhadra, U., Birchler, J.A. Cell (1999)
- Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent. Pal-Bhadra, M., Bhadra, U., Birchler, J.A. Cell (1997)
- TAFs and TFIIA mediate differential utilization of the tandem Adh promoters. Hansen, S.K., Tjian, R. Cell (1995)
- Effects of differential alcohol dehydrogenase activity on the developmental toxicity of ethanol in Drosophila melanogaster. Ranganathan, S., Davis, D.G., Leeper, J.D., Hood, R.D. Teratology (1987)
- Acetaldehyde utilization and toxicity in Drosophila adults lacking alcohol dehydrogenase or aldehyde oxidase. David, J.R., Daly, K., Van Herrewege, J. Biochem. Genet. (1984)
- Teratogenicity and toxicity of ethylene glycol monomethyl ether (2-methoxyethanol) in Drosophila melanogaster: involvement of alcohol dehydrogenase activity. Eisses, K.T. Teratog., Carcinog. Mutagen. (1989)
- Molecular analysis of the Adh region of the genome of Drosophila melanogaster. Chia, W., Karp, R., McGill, S., Ashburner, M. J. Mol. Biol. (1985)
- The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. I. Characterization of deficiencies and mapping of ADH and visible mutations. Woodruff, R.C., Ashburner, M. Genetics (1979)
- Protein variation in Adh and Adh-related in Drosophila pseudoobscura. Linkage disequilibrium between single nucleotide polymorphisms and protein alleles. Schaeffer, S.W., Walthour, C.S., Toleno, D.M., Olek, A.T., Miller, E.L. Genetics (2001)
- Partial Characterization and Evolution of Adh-Adhr in Drosophila dunni. Colón-Parrilla, W.V., Pérez-Chiesa, I. Biochem. Genet. (2007)
- Drosophila fat body protein P6 and alcohol dehydrogenase are derived from a common ancestral protein. Rat, L., Veuille, M., Lepesant, J.A. J. Mol. Evol. (1991)
- Both early and late Drosophila chorion gene promoters confer correct temporal, tissue and sex specificity on a reporter Adh gene. Romano, C.P., Bienz-Tadmor, B., Mariani, B.D., Kafatos, F.C. EMBO J. (1988)
- Site-directed mutations reveal long-range compensatory interactions in the Adh gene of Drosophila melanogaster. Parsch, J., Tanda, S., Stephan, W. Proc. Natl. Acad. Sci. U.S.A. (1997)
- In vitro suppression of a nonsense mutant of Drosophila melanogaster. Kubli, E., Schmidt, T., Martin, P.F., Sofer, W. Nucleic Acids Res. (1982)
- Isolation and characterization of the genomic region from Drosophila kuntzei containing the Adh and Adhr genes. Oppentocht, J.E., van Delden, W., van de Zande, L. Mol. Biol. Evol. (2002)
- Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. Chen, Z., Jiang, J.C., Lin, Z.G., Lee, W.R., Baker, M.E., Chang, S.H. Biochemistry (1993)
- A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. Abel, T., Bhatt, R., Maniatis, T. Genes Dev. (1992)
- Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers. Falb, D., Maniatis, T. Mol. Cell. Biol. (1992)
- A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Abel, T., Michelson, A.M., Maniatis, T. Development (1993)
- Activation and repression of Drosophila alcohol dehydrogenase distal transcription by two steroid hormone receptor superfamily members binding to a common response element. Ayer, S., Walker, N., Mosammaparast, M., Nelson, J.P., Shilo, B.Z., Benyajati, C. Nucleic Acids Res. (1993)
- Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism. Ren, B., Maniatis, T. EMBO J. (1998)
- Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb oncoproteins. England, B.P., Admon, A., Tjian, R. Proc. Natl. Acad. Sci. U.S.A. (1992)
- The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VI. Induced revertants of scutoid. Ashburner, M., Detwiler, C., Tsubota, S., Woodruff, R.C. Genetics (1983)
- Climatic selection on genes and traits after a 100 year-old invasion: a critical look at the temperate-tropical clines in Drosophila melanogaster from eastern Australia. Hoffmann, A.A., Weeks, A.R. Genetica (2007)
- The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation. Ashburner, M., Tsubota, S., Woodruff, R.C. Genetics (1982)
- Deletion scanning of the regulatory sequences of the Fbp1 gene of Drosophila melanogaster using P transposase-induced deficiencies. Lapie, P., Nasr, F., Lepesant, J.A., Deutsch, J. Genetics (1993)
- Nonfixed duplication containing the Adh gene and a truncated form of the Adhr gene in the Drosophila funebris species group: different modes of evolution of Adh relative to Adhr in Drosophila. Amador, A., Juan, E. Mol. Biol. Evol. (1999)
- Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis. Benach, J., Winberg, J.O., Svendsen, J.S., Atrian, S., Gonzàlez-Duarte, R., Ladenstein, R. J. Mol. Biol. (2005)
- Site-directed mutagenesis of glycine-14 and two "critical" cysteinyl residues in Drosophila alcohol dehydrogenase. Chen, Z., Lu, L., Shirley, M., Lee, W.R., Chang, S.H. Biochemistry (1990)
- Protein engineering of Drosophila alcohol dehydrogenase. The hydroxyl group of Tyr152 is involved in the active site of the enzyme. Albalat, R., González-Duarte, n.u.l.l., Atrian, S. FEBS Lett. (1992)