Gene Review:
Sp1 - CG1343 gene product from transcript CG1343-RE
Drosophila melanogaster
Synonyms:
CG1343, D-Sp1, D-Sp8, D.Sp1, Dmel\CG1343, ...
- Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1. Athanikar, J.N., Sanchez, H.B., Osborne, T.F. Mol. Cell. Biol. (1997)
- p53 and Sp1 interact and cooperate in the tumor necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat. Gualberto, A., Baldwin, A.S. J. Biol. Chem. (1995)
- Interaction between transcription factors Sp1 and YY1. Seto, E., Lewis, B., Shenk, T. Nature (1993)
- Sp1-mediated transactivation of LamC1 promoter and coordinated expression of laminin-gamma1 and Sp1 in human hepatocellular carcinomas. Liétard, J., Musso, O., Théret, N., L'Helgoualc'h, A., Campion, J.P., Yamada, Y., Clément, B. Am. J. Pathol. (1997)
- Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. Xu, Q., Ji, Y.S., Schmedtje, J.F. J. Biol. Chem. (2000)
- Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Hoey, T., Weinzierl, R.O., Gill, G., Chen, J.L., Dynlacht, B.D., Tjian, R. Cell (1993)
- Mechanism of transcriptional activation by Sp1: evidence for coactivators. Pugh, B.F., Tjian, R. Cell (1990)
- Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Courey, A.J., Holtzman, D.A., Jackson, S.P., Tjian, R. Cell (1989)
- The role of buttonhead and Sp1 in the development of the ventral imaginal discs of Drosophila. Estella, C., Rieckhof, G., Calleja, M., Morata, G. Development (2003)
- Common and diverged functions of the Drosophila gene pair D-Sp1 and buttonhead. Schöck, F., Purnell, B.A., Wimmer, E.A., Jäckle, H. Mech. Dev. (1999)
- Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo. Farmer, G., Colgan, J., Nakatani, Y., Manley, J.L., Prives, C. Mol. Cell. Biol. (1996)
- Detection and characterization of Sp1 binding activity in human chondrocytes and its alterations during chondrocyte dedifferentiation. Dharmavaram, R.M., Liu, G., Mowers, S.D., Jimenez, S.A. J. Biol. Chem. (1997)
- Drosophila head segmentation factor buttonhead interacts with the same TATA box-binding protein-associated factors and in vivo DNA targets as human Sp1 but executes a different biological program. Schöck, F., Sauer, F., Jäckle, H., Purnell, B.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- buttonhead and D-Sp1: a novel Drosophila gene pair. Wimmer, E.A., Frommer, G., Purnell, B.A., Jäckle, H. Mech. Dev. (1996)
- Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line. Gartel, A.L., Goufman, E., Najmabadi, F., Tyner, A.L. Oncogene (2000)
- Base sequence discrimination by zinc-finger DNA-binding domains. Nardelli, J., Gibson, T.J., Vesque, C., Charnay, P. Nature (1991)
- Molecular Mechanisms of Transactivation and Doxorubicin-mediated Repression of survivin Gene in Cancer Cells. Estève, P.O., Chin, H.G., Pradhan, S. J. Biol. Chem. (2007)
- c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1. Kardassis, D., Papakosta, P., Pardali, K., Moustakas, A. J. Biol. Chem. (1999)
- Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. Näär, A.M., Beaurang, P.A., Robinson, K.M., Oliner, J.D., Avizonis, D., Scheek, S., Zwicker, J., Kadonaga, J.T., Tjian, R. Genes Dev. (1998)
- Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter. Yieh, L., Sanchez, H.B., Osborne, T.F. Proc. Natl. Acad. Sci. U.S.A. (1995)
- An Sp1/KLF binding site is important for the activity of a Polycomb group response element from the Drosophila engrailed gene. Brown, J.L., Grau, D.J., DeVido, S.K., Kassis, J.A. Nucleic Acids Res. (2005)
- Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants. Silverman, E.S., Du, J., De Sanctis, G.T., Rådmark, O., Samuelsson, B., Drazen, J.M., Collins, T. Am. J. Respir. Cell Mol. Biol. (1998)
- Contrasting mammalian parathyroid hormone (PTH) promoters: nuclear factor-Y binds to a deoxyribonucleic acid element unique to the human PTH promoter and acts as a transcriptional enhancer. Alimov, A.P., Langub, M.C., Malluche, H.H., Park-Sarge, O.K., Koszewski, N.J. Endocrinology (2004)
- Transcriptional activation domains of the single-minded bHLH protein are required for CNS midline cell development. Franks, R.G., Crews, S.T. Mech. Dev. (1994)
- Dynamic transcriptional regulatory complexes, including E2F4, p107, p130, and Sp1, control fibroblast growth factor receptor 1 gene expression during myogenesis. Parakati, R., DiMario, J.X. J. Biol. Chem. (2005)
- Functional interference of Sp1 and NF-kappaB through the same DNA binding site. Hirano, F., Tanaka, H., Hirano, Y., Hiramoto, M., Handa, H., Makino, I., Scheidereit, C. Mol. Cell. Biol. (1998)
- In vitro chromatin assembly of the HIV-1 promoter. ATP-dependent polar repositioning of nucleosomes by Sp1 and NFkappaB. Widlak, P., Gaynor, R.B., Garrard, W.T. J. Biol. Chem. (1997)
- The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro. Zehring, W.A., Greenleaf, A.L. J. Biol. Chem. (1990)
- Expression of the alpha 5 integrin subunit gene promoter is positively regulated by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro. Larouche, K., Leclerc, S., Salesse, C., Guérin, S.L. J. Biol. Chem. (2000)
- The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells. Qin, H., Sun, Y., Benveniste, E.N. J. Biol. Chem. (1999)
- Identification and analysis of cabut orthologs in invertebrates and vertebrates. Muñoz-Descalzo, S., Belacortu, Y., Paricio, N. Dev. Genes Evol. (2007)
- Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements. Dynlacht, B.D., Attardi, L.D., Admon, A., Freeman, M., Tjian, R. Genes Dev. (1989)
- The role of Sp1 and Sp3 in the constitutive DPYD gene expression. Zhang, X., Li, L., Fourie, J., Davie, J.R., Guarcello, V., Diasio, R.B. Biochim. Biophys. Acta (2006)
- Selective Sp1 binding is critical for maximal activity of the human c-kit promoter. Park, G.H., Plummer, H.K., Krystal, G.W. Blood (1998)