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Gene Review

gammaCOP  -  Coat Protein (coatomer) gamma

Drosophila melanogaster

Synonyms: 0573/02, 573.02, CG1528, COPIgamma, Coatomer subunit gamma, ...
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High impact information on gammaCop

  • The gamma-COP subunit of the coatomer is believed to mediate the binding to the cytoplasmic dilysine motifs of membrane proteins [1].
  • It was inserted in the gammaCOP locus on chromosome 3R. gammaCOP is a component of the COPI coatomer involved in membrane traffic [2].
  • GM130 is involved in the docking and fusion of coatomer (COP I) coated vesicles to the Golgi membranes; it also regulates the fragmentation and subsequent reassembly of the Golgi complex during mitosis [3].


  1. Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. Hahn, Y., Lee, Y.J., Yun, J.H., Yang, S.K., Park, C.W., Mita, K., Huh, T.L., Rhee, M., Chung, J.H. FEBS Lett. (2000) [Pubmed]
  2. Expression of COPI components during development of Drosophila melanogaster. Grieder, N.C., Kloter, U., Gehring, W.J. Gene Expr. Patterns (2005) [Pubmed]
  3. A new member of the GM130 golgin subfamily is expressed in the optic lobe anlagen of the metamorphosing brain of Manduca sexta. Wang, C.M., Chen, C.L., Robertson, H.M., Fahrbach, S.E. J. Insect Sci. (2003) [Pubmed]
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