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Gene Review

COPG2  -  coatomer protein complex, subunit gamma 2

Homo sapiens

Synonyms: 2-COP, Coatomer subunit gamma-2, Gamma-2-COP, Gamma-2-coat protein, gamma-2-COP
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High impact information on COPG2


Biological context of COPG2


Other interactions of COPG2

  • Structures of Fugu and human MEST, COPG2 and UCN genes are very similar [4].

Analytical, diagnostic and therapeutic context of COPG2

  • Sequence analysis revealed the presence of MEST and three additional genes which show homology to plant DNBP (DNA-Binding Protein), vertebrate COPG2 (Coat Protein Gamma 2), as well as to human and mouse UCN (Urocortin) [4].


  1. gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. Blagitko, N., Schulz, U., Schinzel, A.A., Ropers, H.H., Kalscheuer, V.M. Hum. Mol. Genet. (1999) [Pubmed]
  2. Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. Bonora, E., Bacchelli, E., Levy, E.R., Blasi, F., Marlow, A., Monaco, A.P., Maestrini, E. Mol. Psychiatry (2002) [Pubmed]
  3. The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting. Yamasaki, K., Hayashida, S., Miura, K., Masuzaki, H., Ishimaru, T., Niikawa, N., Kishino, T. Genomics (2000) [Pubmed]
  4. Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis. Brunner, B., Grützner, F., Yaspo, M.L., Ropers, H.H., Haaf, T., Kalscheue, V.M. Chromosome Res. (2000) [Pubmed]
  5. The COPG2, DCN, and SDHD genes are biallelically expressed in cattle. Khatib, H. Mamm. Genome (2005) [Pubmed]
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