High impact information on unc-13

• Therefore, UNC-13 binding to the N terminus of syntaxin may promote the open configuration of syntaxin [1].
• Thus, it is likely that UNC-13 primes synaptic vesicles for fusion by promoting the open configuration of syntaxin [1].
• Dunc-13 contained a C1 lipid-binding motif and two C2 calcium-binding domains, and its expression was restricted to neurons [2].
• Drosophila UNC-13 is essential for synaptic transmission [2].
• We cloned the Drosophila homolog (Dunc-13) and characterized its function using a combination of electrophysiology and ultrastructural analyses [2].

Biological context of unc-13

• The N terminus of syntaxin also binds the presynaptic protein UNC-13 (ref. 5). Studies in mouse, Drosophila and Caenorhabditis elegans suggest that UNC-13 functions at a post-docking step of exocytosis, most likely during synaptic vesicle priming [1].

Anatomical context of unc-13

• The UNC-13 protein family has been suggested to be critical for synaptic vesicle dynamics based on its interactions with Syntaxin, Munc-18 and Doc 2alpha [2].

Other interactions of unc-13

• Among these six were a homolog of the diacylglycerol-binding protein, UNC13, and a protein, CRAG, related to Rab3 GTPase exchange proteins [3].

References