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Gene Review

unc-13  -  Protein UNC-13

Caenorhabditis elegans

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Disease relevance of unc-13


Psychiatry related information on unc-13


High impact information on unc-13

  • However, the number of synaptic vesicles at neuromuscular junctions was two- to threefold greater in unc-13 mutants than in wild-type animals [3].
  • Mutants of unc-13 had normal nervous system architecture, and the densities of synapses and postsynaptic receptors were normal at the neuromuscular junction [3].
  • Even when priming was restored, synaptic transmission remained defective in unc-13 mutants, suggesting that UNC-13 is also required for other aspects of secretion [4].
  • These findings confirm that the unc-13 gene product has binding sites similar to those of protein kinase C and may be a component of an alternative transduction pathway of the diacylglycerol signal to a different effector function in the nervous system [5].
  • In order to evaluate the function of the individual members of this multigene family, we sought to recover amber (UAG)-suppressing mutations from reversion experiments with animals carrying amber mutations in a nervous system-affecting gene (unc-13) or a sex-determining gene (tra-3) [6].

Biological context of unc-13


Anatomical context of unc-13

  • Priming defective unc-13 mutants show a dramatic reduction in plasma membrane-contacting vesicles, suggesting these vesicles largely represent the primed vesicle pool at the C. elegans neuromuscular junction [11].
  • Our data suggest that the function of unc-13 in C. elegans is conserved in mammals and that Munc13s act as plasma membrane proteins in nerve terminals [12].

Associations of unc-13 with chemical compounds


Other interactions of unc-13


Analytical, diagnostic and therapeutic context of unc-13


  1. A bacteriophage T7-based expression vector, pBT7, with color selection for the recombinant. Maruyama, I.N., Mikawa, Y.G., Maruyama, H.I. Gene (1993) [Pubmed]
  2. Identification of Munc13-3 as a candidate gene for critical-period neuroplasticity in visual cortex. Yang, C.B., Zheng, Y.T., Li, G.Y., Mower, G.D. J. Neurosci. (2002) [Pubmed]
  3. UNC-13 is required for synaptic vesicle fusion in C. elegans. Richmond, J.E., Davis, W.S., Jorgensen, E.M. Nat. Neurosci. (1999) [Pubmed]
  4. Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13. McEwen, J.M., Madison, J.M., Dybbs, M., Kaplan, J.M. Neuron (2006) [Pubmed]
  5. A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Maruyama, I.N., Brenner, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  6. Differential expression of five tRNA(UAGTrp) amber suppressors in Caenorhabditis elegans. Kondo, K., Hodgkin, J., Waterston, R.H. Mol. Cell. Biol. (1988) [Pubmed]
  7. Expression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system. Kohn, R.E., Duerr, J.S., McManus, J.R., Duke, A., Rakow, T.L., Maruyama, H., Moulder, G., Maruyama, I.N., Barstead, R.J., Rand, J.B. Mol. Biol. Cell (2000) [Pubmed]
  8. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen, R.C., Jones, S.J., Rose, A.M. Mol. Gen. Genet. (2000) [Pubmed]
  9. Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. Betz, A., Okamoto, M., Benseler, F., Brose, N. J. Biol. Chem. (1997) [Pubmed]
  10. A second informational suppressor, SUP-7 X, in Caenorhabditis elegans. Waterston, R.H. Genetics (1981) [Pubmed]
  11. Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans. Gracheva, E.O., Burdina, A.O., Holgado, A.M., Berthelot-Grosjean, M., Ackley, B.D., Hadwiger, G., Nonet, M.L., Weimer, R.M., Richmond, J.E. PLoS Biol. (2006) [Pubmed]
  12. Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. Brose, N., Hofmann, K., Hata, Y., Südhof, T.C. J. Biol. Chem. (1995) [Pubmed]
  13. The effect of gamma radiation on recombination frequency in Caenorhabditis elegans. Kim, J.S., Rose, A.M. Genome (1987) [Pubmed]
  14. UNC-13 interaction with syntaxin is required for synaptic transmission. Madison, J.M., Nurrish, S., Kaplan, J.M. Curr. Biol. (2005) [Pubmed]
  15. Synaptic exocytosis and nervous system development impaired in Caenorhabditis elegans unc-13 mutants. Maruyama, H., Rakow, T.L., Maruyama, I.N. Neuroscience (2001) [Pubmed]
  16. Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Muñoz, M.J., Riddle, D.L. Genetics (2003) [Pubmed]
  17. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Wang, Y., Tissenbaum, H.A. Mech. Ageing Dev. (2006) [Pubmed]
  18. Genetic organization of the region around UNC-15 (I), a gene affecting paramyosin in Caenorhabditis elegans. Rose, A.M., Baillie, D.L. Genetics (1980) [Pubmed]
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