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Gene Review:

Optix - CG18455 gene product from transcript...

Drosophila melanogaster

Synonyms: CG18455, D-Six3, Dmel\CG18455, Dsix3, Homeobox protein SIX3, ...

Kenyon, K.L. et al., Ostrin, E.J. et al., Pasquier, L. et al., Seimiya, M. et al., Seo, H.C. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Optix

Initial analysis reveals three genes, eyes absent, shifted, and Optix, as novel direct targets of Ey [1].
The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism [2].
Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development [3].
Similar to so, both D-Six3 and D-Six4 are initially expressed at the blastoderm stage in narrow regions of the prospective head and during later stages in specific groups of head midline neurectodermal cells [4].

Biological context of Optix

Two members from the Six class of homeobox transcription factors, Sine oculis (SO) and Optix, function during development of the fly visual system [5].
These results suggest that optix is involved in eye morphogenesis by an eyeless-independent mechanism [2].
Among the genetic factors, SIX3, which is considered to be the functional orthologue of Drosophila genes sine oculis (so) and optix, has been found to be mutated in the homeodomain, in some patients with HPE (HPE2 on chromosome 2p21) [6].

Anatomical context of Optix

In this study, we report the identification of two novel factors that participate in specific partnerships with Sine oculis and Optix during photoreceptor neurons formation and in eye progenitor cells [5].

References

Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Ostrin, E.J., Li, Y., Hoffman, K., Liu, J., Wang, K., Zhang, L., Mardon, G., Chen, R. Genome Res. (2006) [Pubmed]
The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism. Seimiya, M., Gehring, W.J. Development (2000) [Pubmed]
Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development. Kenyon, K.L., Yang-Zhou, D., Cai, C.Q., Tran, S., Clouser, C., Decene, G., Ranade, S., Pignoni, F. Dev. Biol. (2005) [Pubmed]
Six class homeobox genes in drosophila belong to three distinct families and are involved in head development. Seo, H.C., Curtiss, J., Mlodzik, M., Fjose, A. Mech. Dev. (1999) [Pubmed]
Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. Kenyon, K.L., Li, D.J., Clouser, C., Tran, S., Pignoni, F. Dev. Dyn. (2005) [Pubmed]
A new mutation in the six-domain of SIX3 gene causes holoprosencephaly. Pasquier, L., Dubourg, C., Blayau, M., Lazaro, L., Le Marec, B., David, V., Odent, S. Eur. J. Hum. Genet. (2000) [Pubmed]

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six3b	Danio rerio
LOC717027	Macaca mulatta

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