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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

OR4Q3  -  olfactory receptor, family 4, subfamily Q,...

Homo sapiens

Synonyms: C14orf13, HSA6, OR14-3, OR4Q4, Olfactory receptor 4Q3, ...
 
 
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High impact information on OR4Q3

  • Evolutionary chromosomal breakpoints between CFA1 and the corresponding human chromosomes (HSA6, HSA9, HSA18, and HSA19) were located within 1 to 5 Mb based upon the human genome sequence [1].
  • Two homologous chromosome segments in human could be detected, ESR-CGA on human chromosome 6 (HSA6) and IFNA-RLN-GRP78 on human chromosome 9 (HSA9) [2].
  • Of the ten ASPs used, HSA6 and 16 ASPs showed complete synteny conservation of individual arms as single blocks/ arms both in pig and horse [3].
  • The CMSD locus maps to CFA1 (LOD > 18) and haplotype analysis narrowed the CFA1 target region to a 15-Mb segment that contains orthologs of genes on HSA6, including PARK2, the gene for the ubiquitin ligase parkin [4].
  • Thirteen type I loci from HSA4q, HSA6p, HSA7q and HSA12q were comparatively FISH-mapped in four river buffalo and sheep chromosomes [5].
 

Biological context of OR4Q3

  • The study of this complete BAC contig showed that human chromosomal fragments homologs of this heavily rearranged QTL region are all located in the region of HSA6 that surrounds the centromere [6].

References

  1. Comparative radiation hybrid map of canine chromosome 1 incorporating SNP and indel polymorphisms. Housley, D.J., Ritzert, E., Venta, P.J. Genomics (2004) [Pubmed]
  2. A physically anchored linkage map of pig chromosome 1 uncovers sex- and position-specific recombination rates. Ellegren, H., Chowdhary, B.P., Fredholm, M., Høyheim, B., Johansson, M., Bräuner Nielsen, P.B., Thomsen, P.D., Andersson, L. Genomics (1994) [Pubmed]
  3. Zoo-FISH with microdissected arm specific paints for HSA2, 5, 6, 16, and 19 refines known homology with pig and horse chromosomes. Chaudhary, R., Raudsepp, T., Guan, X.Y., Zhang, H., Chowdhary, B.P. Mamm. Genome (1998) [Pubmed]
  4. Genetic mapping of canine multiple system degeneration and ectodermal dysplasia loci. O'Brien, D.P., Johnson, G.S., Schnabel, R.D., Khan, S., Coates, J.R., Johnson, G.C., Taylor, J.F. J. Hered. (2005) [Pubmed]
  5. Thirteen type I loci from HSA4q, HSA6p, HSA7q and HSA12q were comparatively FISH-mapped in four river buffalo and sheep chromosomes. Di Meo, G.P., Perucatti, A., Schibler, L., Incarnato, D., Ferrara, L., Cribiu, E.P., Iannuzzi, L. Cytogenet. Cell Genet. (2000) [Pubmed]
  6. High resolution physical map of porcine chromosome 7 QTL region and comparative mapping of this region among vertebrate genomes. Demars, J., Riquet, J., Feve, K., Gautier, M., Morisson, M., Demeure, O., Renard, C., Chardon, P., Milan, D. BMC Genomics (2006) [Pubmed]
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