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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sr-CII  -  Scavenger receptor class C, type II

Drosophila melanogaster

Synonyms: CG8856, CT25430, Dmel\CG8856, SR-CII, dSR-CII
 
 
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Disease relevance of Sr-CII

  • Our findings reveal that Drosophila macrophages express multiple pattern recognition receptors and that the Drosophila scavenger receptor, dSR-CI, is one such receptor capable of recognizing both gram-negative and gram-positive bacteria, but not yeast [1].
 

High impact information on Sr-CII

  • (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila [2].
  • Variation in SR-CII and 18-wheeler, however, has effects that are more general [3].
  • Some larger SPs may contain one or more regions important for protein-protein interactions, including clip domains, low-density lipoprotein receptor class A repeats, and scavenger receptor cysteine-rich domains [4].

References

  1. Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria. Rämet, M., Pearson, A., Manfruelli, P., Li, X., Koziel, H., Göbel, V., Chung, E., Krieger, M., Ezekowitz, R.A. Immunity (2001) [Pubmed]
  2. Eater: a big bite into phagocytosis. Ertürk-Hasdemir, D., Silverman, N. Cell (2005) [Pubmed]
  3. Genetic Variation in Drosophila melanogaster Resistance to Infection: A Comparison Across Bacteria. Lazzaro, B.P., Sackton, T.B., Clark, A.G. Genetics (2006) [Pubmed]
  4. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross, J., Jiang, H., Kanost, M.R., Wang, Y. Gene (2003) [Pubmed]
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