Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Sr-CI - Scavenger receptor class C, type I

Drosophila melanogaster

Synonyms: CG4099, CT9876, D-SR-CI, DSR-CI, Dmel\CG4099, ...

Abrams, J.M. et al., Stuart, L.M. et al., Pearson, A. et al., Ross, J. et al., Lazzaro, B.P., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sr-CI

In an on-going forward genetic screen, we identify the Drosophila melanogaster scavenger receptor Croquemort as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors for bacteria [1].

High impact information on Sr-CI

Expression cloning was used to isolate from L2 cells a cDNA that encodes a third class (class C) of scavenger receptor, Drosophila SR-CI (dSR-CI). dSR-CI expression was restricted to macrophages/hemocytes during embryonic development [2].
Macrophages in Drosophila embryos and L2 cells exhibit scavenger receptor-mediated endocytosis [3].
The Drosophila Schneider L2, but not the Kc, cell line also exhibited a scavenger receptor-mediated endocytic pathway similar to its mammalian counterpart [3].
The Drosophila Class B Scavenger Receptor NinaD-I Is a Cell Surface Receptor Mediating Carotenoid Transport for Visual Chromophore Synthesis [4].
Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including pathogenic bacteria during phagocytosis [5].

Biological context of Sr-CI

They also establish additional systems for the investigation of endocytosis in Drosophila and scavenger receptor function in disease, host defense, and development [3].

Associations of Sr-CI with chemical compounds

Some larger SPs may contain one or more regions important for protein-protein interactions, including clip domains, low-density lipoprotein receptor class A repeats, and scavenger receptor cysteine-rich domains [6].

Analytical, diagnostic and therapeutic context of Sr-CI

Scavenger receptor-like endocytosis was observed in Drosophila melanogaster embryos and in primary embryonic cell cultures [3].

References

Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. Stuart, L.M., Deng, J., Silver, J.M., Takahashi, K., Tseng, A.A., Hennessy, E.J., Ezekowitz, R.A., Moore, K.J. J. Cell Biol. (2005) [Pubmed]
Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster. Pearson, A., Lux, A., Krieger, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Macrophages in Drosophila embryos and L2 cells exhibit scavenger receptor-mediated endocytosis. Abrams, J.M., Lux, A., Steller, H., Krieger, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
The Drosophila Class B Scavenger Receptor NinaD-I Is a Cell Surface Receptor Mediating Carotenoid Transport for Visual Chromophore Synthesis. Voolstra, O., Kiefer, C., Hoehne, M., Welsch, R., Vogt, K., von Lintig, J. Biochemistry (2006) [Pubmed]
Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans. Lazzaro, B.P. Genetics (2005) [Pubmed]
Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross, J., Jiang, H., Kanost, M.R., Wang, Y. Gene (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.