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Gene Review

HPRT1  -  hypoxanthine phosphoribosyltransferase 1

Canis lupus familiaris

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Disease relevance of HPRT1


High impact information on HPRT1

  • In order to develop such controls for studying cytokine mRNA expression in dogs, DNA sequence encoding a full-length canine HPRT protein has been obtained [2].
  • The data from the present study suggest that there may be processed HPRT pseudogenes in dogs [2].

Analytical, diagnostic and therapeutic context of HPRT1

  • Selection of HPRT primers as controls for determination of mRNA expression in dogs by RT-PCR [2].
  • Three pairs of canine HPRT primers designed and tested in the present study were able to differentiate between cDNA and genomic DNA under specific PCR conditions [2].


  1. Elevated intracellular glycine associated with hypoxanthine-guanine phosphoribosyltransferase deficiency in glioma cells. Skaper, S.D., Seegmiller, J.E. J. Neurochem. (1977) [Pubmed]
  2. Selection of HPRT primers as controls for determination of mRNA expression in dogs by RT-PCR. Johnson, C.M., Yang, S., Sellins, K.S., Frank, G.R. Vet. Immunol. Immunopathol. (2004) [Pubmed]
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