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Gene Review:

GHSR - growth hormone secretagogue receptor

Ovis aries

Kurose, Y. et al., Yan, M. et al.

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Disease relevance of GHSR

We conclude that lowering body weight leads to increased expression of Ob-Rb, ghrelin/GHS-R expression and proportion of NPY cells that express Ob-Rb in the arcuate nucleus [1].

High impact information on GHSR

We measured expression of the leptin receptor (Ob-Rb) and the ghrelin/growth hormone releasing peptide receptor (GHS-R) in the arcuate nucleus of sheep held at either high or low levels of adiposity [1].
Frozen hypothalamic sections of arcuate nucleus were extracted and mRNA levels measured for mRNA for Ob-Rb and GHS-R [1].
Gene expression for both Ob-Rb and GHS-R was higher in Lean animals than in Fat animals, with no difference in expression between Fat and Normal animals [1].
The levels of Pit-1, GHRH-R and GHS-R mRNA were increased after 0.5 h treatment of cells with GHRH and GHRP-2 [2].

References

Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means. Kurose, Y., Iqbal, J., Rao, A., Murata, Y., Hasegawa, Y., Terashima, Y., Kojima, M., Kangawa, K., Clarke, I.J. J. Neuroendocrinol. (2005) [Pubmed]
Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH, pituitary transcription factor-1, GHRH-receptor, GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells. Yan, M., Hernandez, M., Xu, R., Chen, C. Eur. J. Endocrinol. (2004) [Pubmed]

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