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MeSH Review


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Disease relevance of Adiposity


Psychiatry related information on Adiposity


High impact information on Adiposity


Chemical compound and disease context of Adiposity


Biological context of Adiposity


Anatomical context of Adiposity


Associations of Adiposity with chemical compounds

  • A positive association between adiposity and plasma estrogen levels in postmenopausal women has been reported consistently [29].
  • During fasting conditions, however, rates of FFA uptake across the leg were negatively correlated with visceral adiposity as were activities of muscle carnitine palmitoyl transferase and citrate synthase [30].
  • The degree of adiposity and serum are important regulators of HR activity, whereas insulin is stimulatory only at a pharmacologic concentration [31].
  • Overall, testosterone was associated inversely with HDL cholesterol and apo A-I in white boys, while progesterone was related positively to apo A-I in both races after adjusting for age and adiposity [32].
  • Adiponectin, the most abundant adipose-specific protein, has been found to be negatively associated with degree of adiposity and positively associated with insulin sensitivity in Pima Indians and other populations [33].

Gene context of Adiposity

  • There was a significant increase in adipose TNF mRNA levels with increasing adiposity [34].
  • Within each decade, plasma SmC was inversely related to adiposity [35].
  • CONCLUSIONS/INTERPRETATION: We confirmed that adipocyte 11beta-HSD1 mRNA concentrations were associated with adiposity, and showed that genetic variations in the HSD11B1 gene were associated with Type 2 diabetes mellitus, plasma insulin concentrations and insulin action, independent of obesity [36].
  • Pomc gene delivery decreased visceral adiposity and induced uncoupling protein 1 in brown adipose tissue in aged rats [4].
  • Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity, and beta-cell function [37].

Analytical, diagnostic and therapeutic context of Adiposity


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  2. Obesity and coronary heart disease. Garrison, R.J., Higgins, M.W., Kannel, W.B. Curr. Opin. Lipidol. (1996) [Pubmed]
  3. Do upper-body and centralized adiposity measure different aspects of regional body-fat distribution? Relationship to non-insulin-dependent diabetes mellitus, lipids, and lipoproteins. Haffner, S.M., Stern, M.P., Hazuda, H.P., Pugh, J., Patterson, J.K. Diabetes (1987) [Pubmed]
  4. Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats. Li, G., Zhang, Y., Wilsey, J.T., Scarpace, P.J. Diabetologia (2005) [Pubmed]
  5. Effects of moderate weight loss and orlistat on insulin resistance, regional adiposity, and fatty acids in type 2 diabetes. Kelley, D.E., Kuller, L.H., McKolanis, T.M., Harper, P., Mancino, J., Kalhan, S. Diabetes Care (2004) [Pubmed]
  6. Smoking eliminates the protective effect of oral estrogens on the risk for hip fracture among women. Kiel, D.P., Baron, J.A., Anderson, J.J., Hannan, M.T., Felson, D.T. Ann. Intern. Med. (1992) [Pubmed]
  7. Weight, adiposity, and physical activity as determinants of an insulin sensitivity index in pima Indian children. Bunt, J.C., Salbe, A.D., Harper, I.T., Hanson, R.L., Tataranni, P.A. Diabetes Care (2003) [Pubmed]
  8. Serum leptin levels in wild and captive populations of baboons (papio): implications for the ancestral role of leptin. Banks, W.A., Phillips-Conroy, J.E., Jolly, C.J., Morley, J.E. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  9. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Gauguier, D., Froguel, P., Parent, V., Bernard, C., Bihoreau, M.T., Portha, B., James, M.R., Penicaud, L., Lathrop, M., Ktorza, A. Nat. Genet. (1996) [Pubmed]
  10. Partial leptin deficiency and human adiposity. Farooqi, I.S., Keogh, J.M., Kamath, S., Jones, S., Gibson, W.T., Trussell, R., Jebb, S.A., Lip, G.Y., O'Rahilly, S. Nature (2001) [Pubmed]
  11. Moderate exercise and high-density lipoprotein-cholesterol. Observations during a cardiac rehabilitation program. Streja, D., Mymin, D. JAMA (1979) [Pubmed]
  12. Independence of serum lipid levels and dietary habits. The Tecumseh study. Nichols, A.B., Ravenscroft, C., Lamphiear, D.E., Ostrander, L.D. JAMA (1976) [Pubmed]
  13. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. Dixit, V.D., Schaffer, E.M., Pyle, R.S., Collins, G.D., Sakthivel, S.K., Palaniappan, R., Lillard, J.W., Taub, D.D. J. Clin. Invest. (2004) [Pubmed]
  14. Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity. Stewart, P.M., Boulton, A., Kumar, S., Clark, P.M., Shackleton, C.H. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  15. Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity. Ibáñez, L., de Zegher, F. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  16. Retinoids and retinoid receptors in the control of energy balance: novel pharmacological strategies in obesity and diabetes. Villarroya, F., Iglesias, R., Giralt, M. Current medicinal chemistry. (2004) [Pubmed]
  17. Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration. Weyer, C., Tataranni, P.A., Pratley, R.E. Diabetes Care (2000) [Pubmed]
  18. Insulin resistance and breast-cancer risk. Bruning, P.F., Bonfrèr, J.M., van Noord, P.A., Hart, A.A., de Jong-Bakker, M., Nooijen, W.J. Int. J. Cancer (1992) [Pubmed]
  19. Coronary risk factors in a community. Findings in Tecumseh, Michigan. Ostrander, L.D., Lamphiear, D.E. Circulation (1976) [Pubmed]
  20. Relationships of abdominal obesity and hyperinsulinemia to angiographically assessed coronary artery disease in men with known mutations in the LDL receptor gene. Gaudet, D., Vohl, M.C., Perron, P., Tremblay, G., Gagné, C., Lesiège, D., Bergeron, J., Moorjani, S., Després, J.P. Circulation (1998) [Pubmed]
  21. Discrimination between obesity and insulin resistance in the relationship with adiponectin. Abbasi, F., Chu, J.W., Lamendola, C., McLaughlin, T., Hayden, J., Reaven, G.M., Reaven, P.D. Diabetes (2004) [Pubmed]
  22. Learned meal initiation attenuates the anorexic effects of the melanocortin agonist MTII. Benoit, S.C., Clegg, D.J., Barrera, J.G., Seeley, R.J., Woods, S.C. Diabetes (2003) [Pubmed]
  23. Leptin gene expression increases with age independent of increasing adiposity in rats. Li, H., Matheny, M., Nicolson, M., Tümer, N., Scarpace, P.J. Diabetes (1997) [Pubmed]
  24. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. Baldanzi, G., Filigheddu, N., Cutrupi, S., Catapano, F., Bonissoni, S., Fubini, A., Malan, D., Baj, G., Granata, R., Broglio, F., Papotti, M., Surico, N., Bussolino, F., Isgaard, J., Deghenghi, R., Sinigaglia, F., Prat, M., Muccioli, G., Ghigo, E., Graziani, A. J. Cell Biol. (2002) [Pubmed]
  25. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Niswender, K.D., Morrison, C.D., Clegg, D.J., Olson, R., Baskin, D.G., Myers, M.G., Seeley, R.J., Schwartz, M.W. Diabetes (2003) [Pubmed]
  26. Effects of streptozocin-induced diabetes on glucose metabolism and lactate release by isolated fat cells from young lean and older, moderately obese rats. Newby, F.D., Bayo, F., Thacker, S.V., Sykes, M., DiGirolamo, M. Diabetes (1989) [Pubmed]
  27. Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive? Banerji, M.A., Chaiken, R.L., Gordon, D., Kral, J.G., Lebovitz, H.E. Diabetes (1995) [Pubmed]
  28. Coronary heart disease and NIDDM in Japanese-Americans. Fujimoto, W.Y., Bergstrom, R.W., Boyko, E.J., Leonetti, D.L., Newell-Morris, L.L., Wahl, P.W. Diabetes (1996) [Pubmed]
  29. Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. Hankinson, S.E., Willett, W.C., Manson, J.E., Hunter, D.J., Colditz, G.A., Stampfer, M.J., Longcope, C., Speizer, F.E. J. Natl. Cancer Inst. (1995) [Pubmed]
  30. Skeletal muscle utilization of free fatty acids in women with visceral obesity. Colberg, S.R., Simoneau, J.A., Thaete, F.L., Kelley, D.E. J. Clin. Invest. (1995) [Pubmed]
  31. Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes. Kern, P.A., Marshall, S., Eckel, R.H. J. Clin. Invest. (1985) [Pubmed]
  32. Racial (black-white) comparisons of the relationship of levels of endogenous sex hormones to serum lipoproteins during male adolescence: the Bogalusa Heart Study. Srinivasan, S.R., Freedman, D.S., Sundaram, G.S., Webber, L.S., Berenson, G.S. Circulation (1986) [Pubmed]
  33. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Stefan, N., Vozarova, B., Funahashi, T., Matsuzawa, Y., Weyer, C., Lindsay, R.S., Youngren, J.F., Havel, P.J., Pratley, R.E., Bogardus, C., Tataranni, P.A. Diabetes (2002) [Pubmed]
  34. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. Kern, P.A., Saghizadeh, M., Ong, J.M., Bosch, R.J., Deem, R., Simsolo, R.B. J. Clin. Invest. (1995) [Pubmed]
  35. Impaired growth hormone secretion in the adult population: relation to age and adiposity. Rudman, D., Kutner, M.H., Rogers, C.M., Lubin, M.F., Fleming, G.A., Bain, R.P. J. Clin. Invest. (1981) [Pubmed]
  36. 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle. Nair, S., Lee, Y.H., Lindsay, R.S., Walker, B.R., Tataranni, P.A., Bogardus, C., Baier, L.J., Permana, P.A. Diabetologia (2004) [Pubmed]
  37. Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity, and beta-cell function. Bacha, F., Saad, R., Gungor, N., Arslanian, S.A. Diabetes Care (2004) [Pubmed]
  38. Parameters of the three-pool model of the turnover of plasma cholesterol in normal and hyperlipidemic humans. Smith, F.R., Dell, R.B., Noble, R.P., Goodman, D.S. J. Clin. Invest. (1976) [Pubmed]
  39. Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women. Albu, J.B., Murphy, L., Frager, D.H., Johnson, J.A., Pi-Sunyer, F.X. Diabetes (1997) [Pubmed]
  40. Gestational diabetes. Can epidemiology help? Keen, H. Diabetes (1991) [Pubmed]
  41. Regional variation in adipose tissue insulin action and GLUT4 glucose transporter expression in severely obese premenopausal women. Marette, A., Mauriège, P., Marcotte, B., Atgié, C., Bouchard, C., Thériault, G., Bukowiecki, L.J., Marceau, P., Biron, S., Nadeau, A., Després, J.P. Diabetologia (1997) [Pubmed]
  42. Fat distribution is strongly associated with plasma glucose levels and diabetes in Thai adults-the InterASIA study. Stolk, R.P., Suriyawongpaisal, P., Aekplakorn, W., Woodward, M., Neal, B. Diabetologia (2005) [Pubmed]
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