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Gene Review:

DHPS - deoxyhypusine synthase

Bos taurus

McDougall, S., Huang, J.K. et al., Huang, J.K. et al.

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Disease relevance of DHPS

CONCLUSIONS: No difference in bacteriological cure rate, milk production or SCC was evident between lin/neo and pen/DHS intramammary treatments for clinical mastitis in dairy cows during the first 120 days of lactation [1].

High impact information on DHPS

Higher activity of recombinant bovine deoxyhypusine synthase vs. human deoxyhypusine synthase [2].
The deduced bovine eIF5A protein is 100% identical to human eIF5A-1, and the deduced bovine deoxyhypusine synthase protein showed a 93% identity to the human protein [3].
Affected quarters were infused three times at 12 h intervals with either 333 mg lincomycin plus 100 mg neomycin (lin/neo; 197 glands),or 1,000 mg penicillin plus 500 mg dihydrostreptomycin (pen/DHS; 207 glands) [1].

References

Intramammary treatment of clinical mastitis of dairy cows with a combination of lincomycin and neomycin, or penicillin and dihydrostreptomycin. McDougall, S. New Zealand veterinary journal. (2003) [Pubmed]
Higher activity of recombinant bovine deoxyhypusine synthase vs. human deoxyhypusine synthase. Huang, J.K., Tsai, S., Huang, G.H., Gowda, P.G., Walzer, A.M., Wen, L. Protein Expr. Purif. (2004) [Pubmed]
Molecular cloning of bovine eIF5A and deoxyhypusine synthase cDNA. Huang, J.K., Tsai, S., Huang, G.H., Sershon, V.C., Alley, A.M., Wen, L. DNA Seq. (2004) [Pubmed]

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AgaP_AGAP006531	Anopheles gambiae str. PEST
DHS	Arabidopsis thaliana
AGOS_AAL036W	Ashbya gossypii ATCC 10895
dhps-1	Caenorhabditis elegans
DHPS	Canis lupus familiaris
dhps	Danio rerio
CG8005	Drosophila melanogaster
DHPS	Homo sapiens
KLLA0E12695g	Kluyveromyces lactis NRRL Y-1140
DHPS	Macaca mulatta
MGG_09173	Magnaporthe oryzae 70-15
Dhps	Mus musculus
NCU05418	Neurospora crassa OR74A
Os03g0740600	Oryza sativa Japonica Group
DHPS	Pan troglodytes
Dhps	Rattus norvegicus
DYS1	Saccharomyces cerevisiae S288c
SPBC1271.04c	Schizosaccharomyces pombe 972h-
dhps	Xenopus (Silurana) tropicalis

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