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Chemical Compound Review

dihydrostreptomycin     2-[(1S,2R,3R,4S,5R,6R)-5...

Synonyms: Abiocine, SureCN139048, CHEMBL1950576, CHEBI:38291, NSC402956, ...
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Disease relevance of dihydrostreptomycin


High impact information on dihydrostreptomycin


Chemical compound and disease context of dihydrostreptomycin


Biological context of dihydrostreptomycin


Anatomical context of dihydrostreptomycin


Associations of dihydrostreptomycin with other chemical compounds


Gene context of dihydrostreptomycin

  • Forty-five aminoglycoside antibiotics and related compounds were compared for their ability to induce the accumulation of dihydrostreptomycin in Escherichia coli K12 [24].
  • The method includes clean-up using a Sep-Pak C18 cartridge and quantitation using dihydrostreptomycin as an internal standard [25].
  • Streptomycin and dihydrostreptomycin were separated by reversed-phase ion-pair chromatography on LiChrosorb RP-18 and detected by UV absorption (195 nm) [25].
  • From then on, the whole herd was examined weekly for a period of 2 months, and all cows Leptospira-positive by polymerase chain reaction were treated once with dihydrostreptomycin [26].
  • These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel [27].

Analytical, diagnostic and therapeutic context of dihydrostreptomycin


  1. Characterization of group H streptococcal temperate bacteriophage phi 227. Nugent, K.M., Cole, R.M. J. Virol. (1977) [Pubmed]
  2. Effect of enzymatic adenylylation on dihydrostreptomycin accumulation in Escherichia coli carrying an R-factor: model explaining aminoglycoside resistance by inactivating mechanisms. Dickie, P., Bryan, L.E., Pickard, M.A. Antimicrob. Agents Chemother. (1978) [Pubmed]
  3. Inhibition of dihydrostreptomycin binding to Mycobacterium smegmatis by monovalent and divalent cation salts. Beggs, W.H., Andrews, F.A. Antimicrob. Agents Chemother. (1976) [Pubmed]
  4. Killing of intraphagocytic Staphylococcus aureus by dihydrostreptomycin entrapped within liposomes. Bonventre, P.F., Gregoriandis, G. Antimicrob. Agents Chemother. (1978) [Pubmed]
  5. Effect of low concentrations of dihydrostreptomycin on drug resistance in enteric bacteria. Gaines, S.A., Rollins, L.D., Silver, R.P., Washington, M. Antimicrob. Agents Chemother. (1978) [Pubmed]
  6. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. Marcotti, W., van Netten, S.M., Kros, C.J. J. Physiol. (Lond.) (2005) [Pubmed]
  7. Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Vogne, C., Aires, J.R., Bailly, C., Hocquet, D., Plésiat, P. Antimicrob. Agents Chemother. (2004) [Pubmed]
  8. Behavioral ototoxicology. Stebbins, W.C., Rudy, M.C. Environ. Health Perspect. (1978) [Pubmed]
  9. Paromomycin and dihydrostreptomycin binding to Escherichia coli ribosomes. Lando, D., Cousin, M.A., Ojasoo, T., Raymond, J.P. Eur. J. Biochem. (1976) [Pubmed]
  10. Preliminary evaluation of antimicrobial agents for treatment of Leptospira interrogans serovar pomona infection in hamsters and swine. Alt, D.P., Bolin, C.A. Am. J. Vet. Res. (1996) [Pubmed]
  11. Uptake of antibodies in gram-negative bacteria exposed to EDTA-Tris. Wooley, R.E., Jones, M.S., Shotts, E.B. Vet. Microbiol. (1984) [Pubmed]
  12. The effect of chloramphenicol and rifampicin upon degradation of dihydrostreptomycin-induced abnormal protein in Escherichia coli [proceedings]. Carrier, M.J., Kogut, M., Hipkiss, A.R. Biochem. Soc. Trans. (1980) [Pubmed]
  13. Respiration-dependent uptake of dihydrostreptomycin by Escherichia coli. Its irreversible nature and lack of evidence for a uniport process. Nichols, W.W., Young, S.N. Biochem. J. (1985) [Pubmed]
  14. Effect of dihydrostreptomycin on active transport in isolated bacterial membrane vesicles. Eagon, R.G., Hartle, R.J., Rake, J.B., Abdel-Sayed, S. Antimicrob. Agents Chemother. (1982) [Pubmed]
  15. The kinetics of dihydrostreptomycin uptake in Pseudomonas putida membrane vesicles: absence of inhibition by cations. Thomson, T.B., Crider, B.P., Eagon, R.G. J. Antimicrob. Chemother. (1985) [Pubmed]
  16. Interaction of the aminoglycoside antibiotic dihydrostreptomycin with the H+-ATPase of mitochondria. Guerrieri, F., Micelli, S., Massagli, C., Gallucci, E., Papa, S. Biochem. Pharmacol. (1984) [Pubmed]
  17. Bioenergetics of dihydrostreptomycin transport by Escherichia coli. Goss, S.R., Spicer, A.B., Nichols, W.W. FEBS Lett. (1988) [Pubmed]
  18. Effects of dihydrostreptomycin on ribosome function in vivo: lack of correlation between changes in ribosome patterns and growth. Kogut, M., Prizant, E. Antimicrob. Agents Chemother. (1975) [Pubmed]
  19. Lack of accumulation of exogenous adenylyl dihydrostreptomycin by whole cells or spheroplasts of Escherichia coli. Garcia-Riestra, C., Perlin, M.H., Lerner, S.A. Antimicrob. Agents Chemother. (1985) [Pubmed]
  20. Determination of streptomycin and dihydrostreptomycin in milk and honey by liquid chromatography with tandem mass spectrometry. van Bruijnsvoort, M., Ottink, S.J., Jonker, K.M., de Boer, E. Journal of chromatography. A. (2004) [Pubmed]
  21. Effect of neomycin and protein S1 on the binding of streptomycin to the ribosome. Grisé-Miron, L., Brakier-Gingras, L. Eur. J. Biochem. (1982) [Pubmed]
  22. Effect of gentamicin on early mortality and later performance of broiler and Leghorn chickens. Vernimb, G.D., Bachmann, H., Panitz, E. Avian Dis. (1976) [Pubmed]
  23. Survival and fertility of antibiotic-treated bovine spermatozoa. Berndtson, W.E., Foote, R.H. J. Dairy Sci. (1976) [Pubmed]
  24. Comparison of aminoglycoside antibiotics with respect to uptake and lethal activity in Escherichia coli. Allen, N.E., Alborn, W.E., Kirst, H.A., Toth, J.E. J. Med. Chem. (1987) [Pubmed]
  25. Determination of streptomycin in serum by high-performance liquid chromatography. Kurosawa, N., Kuribayashi, S., Owada, E., Ito, K., Nioka, M., Arakawa, M., Fukuda, R. J. Chromatogr. (1985) [Pubmed]
  26. Effective treatment with dihydrostreptomycin of naturally infected cows shedding Leptospira interrogans serovar hardjo subtype hardjobovis. Gerritsen, M.J., Koopmans, M.J., Dekker, T.C., De Jong, M.C., Moerman, A., Olyhoek, T. Am. J. Vet. Res. (1994) [Pubmed]
  27. The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells. Kimitsuki, T., Nakagawa, T., Hisashi, K., Komune, S., Uemura, T. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. (1994) [Pubmed]
  28. Detection of incurred dihydrostreptomycin residues in milk by liquid chromatography and preliminary confirmation methods. Suhren, G., Knappstein, K. The Analyst. (1998) [Pubmed]
  29. Modified determination of dihydrostreptomycin in kidney, muscle and milk by HPLC. Abbasi, H., Hellenäs, K.E. The Analyst. (1998) [Pubmed]
  30. Dihydrostreptomycin modifies adaptation and blocks the mechano-electric transducer in chick cochlear hair cells. Kimitsuki, T., Ohmori, H. Brain Res. (1993) [Pubmed]
  31. Clinical trial of three therapeutic regimens for bovine mastitis. Jarp, J., Bugge, H.P., Larsen, S. Vet. Rec. (1989) [Pubmed]
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