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Gene Review

DHPS  -  deoxyhypusine synthase

Homo sapiens

Synonyms: DHS, DS, Deoxyhypusine synthase, MIG13
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Disease relevance of DHPS


High impact information on DHPS

  • Deoxyhypusine synthase is essential for cell division [1].

Chemical compound and disease context of DHPS


Associations of DHPS with chemical compounds


Physical interactions of DHPS


Enzymatic interactions of DHPS


Other interactions of DHPS


Analytical, diagnostic and therapeutic context of DHPS


  1. Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines. Jakus, J., Wolff, E.C., Park, M.H., Folk, J.E. J. Biol. Chem. (1993) [Pubmed]
  2. Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus. Bevec, D., Kappel, B., Jaksche, H., Csonga, R., Hauber, J., Klier, H., Steinkasserer, A. FEBS Lett. (1996) [Pubmed]
  3. Is hypusine essential for eukaryotic cell proliferation?. Park, M.H., Wolff, E.C., Folk, J.E. Trends. Biochem. Sci. (1993) [Pubmed]
  4. Identification and characterization of eukaryotic initiation factor 5A-2. Clement, P.M., Henderson, C.A., Jenkins, Z.A., Smit-McBride, Z., Wolff, E.C., Hershey, J.W., Park, M.H., Johansson, H.E. Eur. J. Biochem. (2003) [Pubmed]
  5. Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins. Joe, Y.A., Wolff, E.C., Park, M.H. J. Biol. Chem. (1995) [Pubmed]
  6. Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis. Lee, Y., Kim, H.K., Park, H.E., Park, M.H., Joe, Y.A. Mol. Cell. Biochem. (2002) [Pubmed]
  7. Protein kinase CK2 phosphorylates and interacts with deoxyhypusine synthase in HeLa cells. Kang, K.R., Chung, S.I. Exp. Mol. Med. (2003) [Pubmed]
  8. Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. Liao, D.I., Wolff, E.C., Park, M.H., Davies, D.R. Structure (1998) [Pubmed]
  9. Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture. Shi, X.P., Yin, K.C., Ahern, J., Davis, L.J., Stern, A.M., Waxman, L. Biochim. Biophys. Acta (1996) [Pubmed]
  10. Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein. Ober, D., Harms, R., Witte, L., Hartmann, T. J. Biol. Chem. (2003) [Pubmed]
  11. Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase. Wolff, E.C., Folk, J.E., Park, M.H. J. Biol. Chem. (1997) [Pubmed]
  12. Structural features of the eIF-5A precursor required for posttranslational synthesis of deoxyhypusine. Joe, Y.A., Park, M.H. J. Biol. Chem. (1994) [Pubmed]
  13. Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1. Mantuano, E., Trettel, F., Olsen, A.S., Lennon, G., Frontali, M., Jodice, C. Gene (1998) [Pubmed]
  14. Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information. Yan, Y.P., Tao, Y., Chen, K.Y. Biochem. J. (1996) [Pubmed]
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