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Gene Review:

nerfin-1 - nervous fingers 1

Drosophila melanogaster

Synonyms: CG13906, Dmel\CG13906, Nerfin, Nerfin-1, nerfin

Stivers, C. et al., Lukowski, C.M. et al., Kuzin, A. et al.

Kuzin, Brody, Moore, Odenwald,

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Disease relevance of nerfin-1

However, after early sublineage development, nerfin-1 expression shifts from NBs to ganglion mother cells (GMCs) but is not expressed in neurons or glia [1].
Insulinoma associated-1 (INSM1, formerly IA-1) is a Cys(2)-His(2) zinc finger transcription factor sharing conserved regions with Caenorhabditis elegans EGL-46 and Drosophila Nerfin-1 [2].

High impact information on nerfin-1

We show that the neural precursor gene prospero is essential for nerfin-1 expression [3].
Differing from nerfin-1, nerfin-2 is expressed only in a subset of brain neurons [1].
During early CNS development, nerfin-1 gene expression is activated in neuroblasts (NBs) prior to lineage formation [1].

References

Nerfin-1 and -2, novel Drosophila Zn-finger transcription factor genes expressed in the developing nervous system. Stivers, C., Brody, T., Kuzin, A., Odenwald, W.F. Mech. Dev. (2000) [Pubmed]
Expression of two insm1-like genes in the developing zebrafish nervous system. Lukowski, C.M., Ritzel, R.G., Waskiewicz, A.J. Gene Expr. Patterns (2006) [Pubmed]
Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS. Kuzin, A., Brody, T., Moore, A.W., Odenwald, W.F. Dev. Biol. (2005) [Pubmed]

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