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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

kto  -  kohtalo

Drosophila melanogaster

Synonyms: Brm @ Kto, CG8491, Dmel\CG8491, Kto, Kto/Med12, ...
 
 
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High impact information on kto

  • Homozygous kto mutant zebrafish embryos show defects in brain, neural crest, and kidney development and die at approximately 6 days postfertilization [1].
  • We isolated two ethylnitrosourea-induced alleles in the gene encoding this protein and named the locus kohtalo (kto) after the homologous locus in Drosophila [1].
  • Mutation of the gene encoding the Mediator component thyroid hormone receptor-associated protein (TRAP)230/MED12 affects the development of multiple systems in zebrafish embryogenesis [1].
  • The Skuld and Kohtalo proteins physically interact in vivo and have synergistic effects when overexpressed, consistent with a skuld kohtalo double-mutant phenotype that is indistinguishable from either single mutant [2].
  • Loss of either blind spot or kohtalo has identical effects on the development of the eye-antennal disc [3].

References

  1. The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., Hukriede, N.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Two subunits of the Drosophila mediator complex act together to control cell affinity. Janody, F., Martirosyan, Z., Benlali, A., Treisman, J.E. Development (2003) [Pubmed]
  3. Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Treisman, J. Development (2001) [Pubmed]
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