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MeSH Review

Optic Disk

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Disease relevance of Optic Disk


High impact information on Optic Disk


Chemical compound and disease context of Optic Disk

  • On the other hand, the fundal vascular features in papilledema seem to be distinguishable by the method used from those associated with optic disk drusen [10].

Biological context of Optic Disk


Anatomical context of Optic Disk


Associations of Optic Disk with chemical compounds

  • Studies using fluorescein angiography have shown that two types of circulatory defects occur in the optic disk and retina of open-angle glaucomatous eyes [16].
  • This effect was dose-dependent and more pronounced in the macula (+17%, P < .001 vs baseline, after 200 mg; and +27%, P < .001 vs baseline, after 400 mg of pentoxifylline) and the peripheral region (+14%, P < .001; and +26%, P < .001) than in the optic disk (+11%, P < .002; and +13%, P < .001) [21].
  • PURPOSE: We examined changes in optic disk topography using confocal scanning laser ophthalmoscopy after reducing intraocular pressure with administration of latanoprost [22].
  • We evaluated the reliability of optic disk area and disk rim area measurements obtained with the Humphrey Retinal Analyzer from ten repeat fundus images each of one eye of ten normal subjects and ten subjects with increased intraocular pressure [23].
  • Optic disk cup filled with triamcinolone [24].

Gene context of Optic Disk


Analytical, diagnostic and therapeutic context of Optic Disk


  1. Proton or stereotactic photon irradiation for posterior uveal melanoma? A planning intercomparison. Höcht, S., Stark, R., Seiler, F., Heufelder, J., Bechrakis, N.E., Cordini, D., Marnitz, S., Kluge, H., Foerster, M.H., Hinkelbein, W. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (2005) [Pubmed]
  2. Oprelvekin-associated bilateral optic disk edema. Peterson, D.C., Inwards, D.J., Younge, B.R. Am. J. Ophthalmol. (2005) [Pubmed]
  3. Fluorescein angiography in acute nonarteritic anterior ischemic optic neuropathy. Arnold, A.C., Hepler, R.S. Am. J. Ophthalmol. (1994) [Pubmed]
  4. Sectorial choroidal ischemia associated with ipsilateral lacrimal gland tumor. Khairallah, M., Ladjimi, A., Messaoud, R., Gharsallah, R., Ben Yahia, S. Am. J. Ophthalmol. (1997) [Pubmed]
  5. Ocular malformations, moyamoya disease, and midline cranial defects: a distinct syndrome. Bakri, S.J., Siker, D., Masaryk, T., Luciano, M.G., Traboulsi, E.I. Am. J. Ophthalmol. (1999) [Pubmed]
  6. Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Treisman, J. Development (2001) [Pubmed]
  7. PAX2 mutations in oligomeganephronia. Salomon, R., Tellier, A.L., Attie-Bitach, T., Amiel, J., Vekemans, M., Lyonnet, S., Dureau, P., Niaudet, P., Gubler, M.C., Broyer, M. Kidney Int. (2001) [Pubmed]
  8. Vertical optic disk diameter: discrepancy between planimetric and SLO measurements. Spencer, A.F., Sadiq, S.A., Pawson, P., Vernon, S.A. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  9. Changes in expression of fibroblast growth factor receptors during development of the mouse retinofugal pathway. Lin, L., Taylor, J.S., Chan, S.O. J. Comp. Neurol. (2002) [Pubmed]
  10. The central vascular pattern of the eyeground in children with drusen of the optic disk. Erkkilä, H. Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology. (1976) [Pubmed]
  11. Large optic disks in the Marshallese population. Maisel, J.M., Pearlstein, C.S., Adams, W.H., Heotis, P.M. Am. J. Ophthalmol. (1989) [Pubmed]
  12. Macular abnormalities and optic disk anomaly associated with a new PAX2 missense mutation. Higashide, T., Wada, T., Sakurai, M., Yokoyama, H., Sugiyama, K. Am. J. Ophthalmol. (2005) [Pubmed]
  13. Influence of nifedipine on the visual fields of patients with optic-nerve-head diseases. Gaspar, A.Z., Flammer, J., Hendrickson, P. European journal of ophthalmology. (1994) [Pubmed]
  14. Evaluation of the circulation in the retina, peripapillary choroid and optic disk in normal-tension glaucoma. Sugiyama, T., Schwartz, B., Takamoto, T., Azuma, I. Ophthalmic Res. (2000) [Pubmed]
  15. Optic disk vasculitis associated with chronic active Epstein-Barr virus infection. Yamamoto, M., Ohga, S., Ohnishi, Y., Inomata, H. Ophthalmologica (2002) [Pubmed]
  16. Circulatory defects of the optic disk and retina in ocular hypertension and high pressure open-angle glaucoma. Schwartz, B. Survey of ophthalmology. (1994) [Pubmed]
  17. Optic nerve morphology may reveal adverse events during prenatal and perinatal life--digital image analysis. Hellström, A. Survey of ophthalmology. (1999) [Pubmed]
  18. Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration. Ziman, M.R., Rodger, J., Chen, P., Papadimitriou, J.M., Dunlop, S.A., Beazley, L.D. Histol. Histopathol. (2001) [Pubmed]
  19. Differential retinal angiogenic response to sustained intravitreal release of VEGF and bFGF in different pigmented rabbit breeds. Erb, M.H., Sioulis, C.E., Kuppermann, B.D., Osann, K., Wong, C.G. Curr. Eye Res. (2002) [Pubmed]
  20. Concurrent bilateral posterior scleritis and Vogt-Koyanagi-Harada disease in a patient with positive rheumatoid factor. Watanabe, K., Kato, T., Hayasaka, S. Ophthalmologica (1997) [Pubmed]
  21. A randomized, placebo-controlled, double-blind crossover study of the effect of pentoxifylline on ocular fundus pulsations. Schmetterer, L., Kemmler, D., Breiteneder, H., Alschinger, C., Koppensteiner, R., Lexer, F., Fercher, A.F., Eichler, H.G., Wolzt, M. Am. J. Ophthalmol. (1996) [Pubmed]
  22. Optic disk topography after medical treatment to reduce intraocular pressure. Bowd, C., Weinreb, R.N., Lee, B., Emdadi, A., Zangwill, L.M. Am. J. Ophthalmol. (2000) [Pubmed]
  23. Reliability of optic nerve head topographic measurements with computerized image analysis. Dandona, L., Quigley, H.A., Jampel, H.D. Am. J. Ophthalmol. (1989) [Pubmed]
  24. Optic disk cup filled with triamcinolone. Sakamoto, T., Koga, H., Noda, Y., Ishibashi, T. Retina (Philadelphia, Pa.) (2002) [Pubmed]
  25. De novo insG619 mutation in PAX2 gene in a Japanese patient with papillorenal syndrome. Yoshimura, K., Yoshida, S., Yamaji, Y., Komori, A., Yoshida, A., Hatae, K., Kubota, T., Ishibashi, T. Am. J. Ophthalmol. (2005) [Pubmed]
  26. Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice. Deiner, M.S., Sretavan, D.W. J. Neurosci. (1999) [Pubmed]
  27. Still a blind spot for osteoporosis prevention and treatment for rheumatoid arthritis. Jolles, B.M., Bogoch, E.R. J. Rheumatol. (2004) [Pubmed]
  28. Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse. Wong, W.T., Rex, T.S., Auricchio, A., Maguire, A.M., Chung, D., Tang, W., Bennett, J. Mol. Vis. (2004) [Pubmed]
  29. Drusen of the optic disk in retinitis pigmentosa. Gartner, S. Am. J. Ophthalmol. (1987) [Pubmed]
  30. Optical coherence tomography study of tilted optic disk associated with macular detachment. Theodossiadis, P.G., Grigoropoulos, V., Emfietzoglou, J., Theodossiadis, G.P. Graefes Arch. Clin. Exp. Ophthalmol. (2006) [Pubmed]
  31. The blind spot in the nicotine replacement therapy literature: assessment of the double-blind in clinical trials. Mooney, M., White, T., Hatsukami, D. Addictive behaviors. (2004) [Pubmed]
  32. Optic disk manifestation in diabetic eyes with low serum albumin: late fluorescein staining and high blood flow velocities in the optic disk. Fujioka, S., Karashima, K., Nishikawa, N., Saito, Y. Jpn. J. Ophthalmol. (2004) [Pubmed]
  33. Lung cancer diagnosed by fine needle biopsy of the optic disk. Shields, J.A., Shields, C.L., Ehya, H. Retina (Philadelphia, Pa.) (2001) [Pubmed]
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