Gene Review:
BTC - betacellulin
Gallus gallus
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High impact information on BTC
- Treatment with TGFalpha or BTC increases levels of TGFbeta1 mRNA in undifferentiated granulosa cells, while the selective inhibitor of mitogen activated protein kinase signaling, U0126, reverses these effects [1].
- The present studies were conducted to establish interactions between transforming growth factor (TGF)-beta and the epidermal growth factor (EGF) family members, TGFalpha and betacellulin (BTC), relative to proliferation and differentiation of granulosa cells in hen ovarian follicles [1].
- Results presented demonstrate expression of TGFbeta isoforms, plus TGFalpha, BTC, and ErbB receptors in prehierarchal follicles, thus establishing the potential for autocrine/paracrine signaling and cross-talk within granulosa cells at the onset of differentiation [1].
References
- Opposing actions of TGFbeta and MAP kinase signaling in undifferentiated hen granulosa cells. Woods, D.C., Haugen, M.J., Johnson, A.L. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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