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Gene Review

Btc  -  betacellulin

Rattus norvegicus

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Disease relevance of Btc


High impact information on Btc

  • Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells [2].
  • These results indicate that, in neonatal STZ-treated rats, a combination of activin A and BTC promoted regeneration of pancreatic beta-cells and improved glucose metabolism in adults [3].
  • In the present study, we used neonatal rats treated with streptozotocin (STZ) to investigate the effects of activin A and BTC on regeneration of pancreatic beta-cells [3].
  • Treatment with activin A and BTC significantly increased the DNA synthesis in preexisting beta-cells, ductal cells, and delta-cells [3].
  • Accordingly, the EGF receptor agonist betacellulin could replicate the effects of exendin 4 in the presence of elevated intracellular cAMP [4].

Biological context of Btc


Anatomical context of Btc


Associations of Btc with chemical compounds


Other interactions of Btc


Analytical, diagnostic and therapeutic context of Btc

  • The pancreatic insulin content and beta-cell mass in rats treated with activin A and BTC were significantly increased compared with the control group on day 8 and at 2 months [3].
  • Molecular cloning and expression of rat betacellulin cDNA [5].
  • Thirty days after pancreatectomy, the beta-cell mass was greater and the insulin content was significantly higher in betacellulin-treated rats than those in control rats [1].


  1. Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats. Li, L., Seno, M., Yamada, H., Kojima, I. Endocrinology (2001) [Pubmed]
  2. Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. Mashima, H., Ohnishi, H., Wakabayashi, K., Mine, T., Miyagawa, J., Hanafusa, T., Seno, M., Yamada, H., Kojima, I. J. Clin. Invest. (1996) [Pubmed]
  3. Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats. Li, L., Yi, Z., Seno, M., Kojima, I. Diabetes (2004) [Pubmed]
  4. Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. MacDonald, P.E., Wang, X., Xia, F., El-kholy, W., Targonsky, E.D., Tsushima, R.G., Wheeler, M.B. J. Biol. Chem. (2003) [Pubmed]
  5. Molecular cloning and expression of rat betacellulin cDNA. Tada, H., Seno, M., Yamada, H., Sasada, R., Igarashi, K. Biochim. Biophys. Acta (2000) [Pubmed]
  6. PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. Yoshida, S., Kajimoto, Y., Yasuda, T., Watada, H., Fujitani, Y., Kosaka, H., Gotow, T., Miyatsuka, T., Umayahara, Y., Yamasaki, Y., Hori, M. Diabetes (2002) [Pubmed]
  7. Epidermal growth factor family members: endogenous mediators of the ovulatory response. Ashkenazi, H., Cao, X., Motola, S., Popliker, M., Conti, M., Tsafriri, A. Endocrinology (2005) [Pubmed]
  8. Betacellulin promotes growth of the gastrointestinal organs and effects a diuresis in normal rats. Howarth, G.S., Bastian, S.E., Dunbar, A.J., Goddard, C. Growth Factors (2003) [Pubmed]
  9. Cloning of rat betacellulin and characterization of its expression in the gastrointestinal tract. Kallincos, N.C., Xian, C.J., Dunbar, A.J., Couper, R.T., Read, L.C. Growth Factors (2000) [Pubmed]
  10. EGF stimulates rat spermatogonial DNA synthesis in seminiferous tubule segments in vitro. Wahab-Wahlgren, A., Martinelle, N., Holst, M., Jahnukainen, K., Parvinen, M., Söder, O. Mol. Cell. Endocrinol. (2003) [Pubmed]
  11. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Fleisig, H., El-Din El-Husseini, A., Vincent, S.R. Neuroscience (2004) [Pubmed]
  12. ARIP cells as a model for pancreatic beta cell growth and development. Silver, K., Yao, F. Pancreas (2001) [Pubmed]
  13. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Kojima, H., Nakamura, T., Fujita, Y., Kishi, A., Fujimiya, M., Yamada, S., Kudo, M., Nishio, Y., Maegawa, H., Haneda, M., Yasuda, H., Kojima, I., Seno, M., Wong, N.C., Kikkawa, R., Kashiwagi, A. Diabetes (2002) [Pubmed]
  14. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Gorogawa, S., Fujitani, Y., Kaneto, H., Hazama, Y., Watada, H., Miyamoto, Y., Takeda, K., Akira, S., Magnuson, M.A., Yamasaki, Y., Kajimoto, Y., Hori, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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