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Gene Review

MAPK1  -  mitogen-activated protein kinase 1

Gallus gallus

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Disease relevance of MAPK1


Psychiatry related information on MAPK1

  • Other agents known to inhibit these enzymes, including the Map kinase inhibitor Rapamycin, also induced memory deficits in a complex, dose- and time-of-administration-dependent, manner [4].

High impact information on MAPK1


Biological context of MAPK1


Anatomical context of MAPK1

  • Indeed, EGF increased the translocation of PKC from the cytosol to the membrane fraction, and increased the activation of p44/42 MAPK, p38 MAPK, and JNK [15].
  • PEDF possibly promotes neurite outgrowth for retinal cells by activating MAPK pathways [1].
  • CONCLUSIONS: T(4), T(3), and T(4)-agarose are pro-angiogenic in the three-dimensional human microvascular endothelial sprouting model, an action that is initiated at the plasma membrane, involves avb3 integrin receptors, and is MAPK-dependent [10].
  • Incubation of COS-1 cells with 8-bromo-cAMP resulted in activation of the MAPK pathway, as determined by Western blotting with antibodies to the phosphorylated (active) form of Erk-1/2, suggesting an indirect pathway to SRC-1 phosphorylation [7].
  • The stem zone is a site of FGF/MAPK signalling and we show that although FGF alone does not mimic paraxial mesoderm signals, it is directly required in epiblast cells for stem zone specification and maintenance [16].

Associations of MAPK1 with chemical compounds

  • In addition, PD 98059 (a MEK inhibitor), SB 203580 (a p38 MAPK inhibitor), and SP 600125 (a JNK inhibitor) blocked the EGF-induced stimulation of [(3)H]-thymidine incorporation and CDK-2/4 expression [15].
  • The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway [17].
  • PDGF-BB also induced tyrosine phosphorylation and nuclear translocation of MAPK [18].
  • The c-fos induction, the increased AP-1 binding activity and the acceleration of DNA synthesis were all attenuated by genistein (100 microM) or MAPK kinase inhibitor (10 or 50 microM PD98059) [18].
  • We found that this stimulatory effect on the S phase is reverted by specific inhibitors of protein kinase C (PKC) and p42/44 mitogen-activated protein kinase (p42/44 MAPK), Ro 31-8220 or PD 98059 [19].

Enzymatic interactions of MAPK1

  • Phosphopeptide mapping of caldesmon immunoprecipitated from [32P]PO4-labelled intact gizzard strips revealed that it is predominantly phosphorylated at mitogen-activated protein kinase sites in unstimulated tissue and that it is stimulated for 1 h with phorbol 12,13-dibutyrate [20].

Regulatory relationships of MAPK1


Other interactions of MAPK1


Analytical, diagnostic and therapeutic context of MAPK1


  1. Pigment epithelium-derived factor promotes neurite outgrowth of retinal cells. Tanimoto, S., Kanamoto, T., Mizukami, M., Aoyama, H., Kiuchi, Y. Hiroshima J. Med. Sci. (2006) [Pubmed]
  2. Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction. Gelb, B.D., Tartaglia, M. Hum. Mol. Genet. (2006) [Pubmed]
  3. Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-kappaB pathways. Khatri, M., Sharma, J.M. Virus Res. (2006) [Pubmed]
  4. Cyclosporin A, FK506 and rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick. Bennett, P.C., Schmidt, L., Lawen, A., Moutsoulas, P., Ng, K.T. Brain Res. (2002) [Pubmed]
  5. Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. Hashimoto, A., Okada, H., Jiang, A., Kurosaki, M., Greenberg, S., Clark, E.A., Kurosaki, T. J. Exp. Med. (1998) [Pubmed]
  6. Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Delfini, M.C., Dubrulle, J., Malapert, P., Chal, J., Pourquié, O. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. 8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein. Rowan, B.G., Garrison, N., Weigel, N.L., O'Malley, B.W. Mol. Cell. Biol. (2000) [Pubmed]
  8. The dissociation of the Fgf-feedback loop controls the limbless state of the neck. Lours, C., Dietrich, S. Development (2005) [Pubmed]
  9. Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite. Smith, T.G., Sweetman, D., Patterson, M., Keyse, S.M., Münsterberg, A. Development (2005) [Pubmed]
  10. Pro-angiogenesis action of thyroid hormone and analogs in a three-dimensional in vitro microvascular endothelial sprouting model. Mousa, S.A., Davis, F.B., Mohamed, S., Davis, P.J., Feng, X. International angiology : a journal of the International Union of Angiology (2006) [Pubmed]
  11. Expression and function of Toll-like receptors in chicken heterophils. Kogut, M.H., Iqbal, M., He, H., Philbin, V., Kaiser, P., Smith, A. Dev. Comp. Immunol. (2005) [Pubmed]
  12. Functions of the MAPK family in vertebrate-development. Krens, S.F., Spaink, H.P., Snaar-Jagalska, B.E. FEBS Lett. (2006) [Pubmed]
  13. Suboptimal cross-linking of antigen receptor induces Syk-dependent activation of p70S6 kinase through protein kinase C and phosphoinositol 3-kinase. Li, H.L., Davis, W., Puré, E. J. Biol. Chem. (1999) [Pubmed]
  14. Cutting edge: extracellular high mobility group box-1 protein is a proangiogenic cytokine. Mitola, S., Belleri, M., Urbinati, C., Coltrini, D., Sparatore, B., Pedrazzi, M., Melloni, E., Presta, M. J. Immunol. (2006) [Pubmed]
  15. Effect of EGF on [(3)H]-thymidine incorporation and cell cycle regulatory proteins in primary cultured chicken hepatocytes: Involvement of Ca(2+)/PKC and MAPKs. Lee, M.Y., Lee, S.H., Kim, Y.H., Heo, J.S., Park, S.H., Lee, J.H., Han, H.J. J. Cell. Biochem. (2006) [Pubmed]
  16. Specification and maintenance of the spinal cord stem zone. Delfino-Machín, M., Lunn, J.S., Breitkreuz, D.N., Akai, J., Storey, K.G. Development (2005) [Pubmed]
  17. The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway. Pyriochou, A., Zhou, Z., Koika, V., Petrou, C., Cordopatis, P., Sessa, W.C., Papapetropoulos, A. J. Cell. Physiol. (2007) [Pubmed]
  18. Platelet-derived growth factor induces cellular growth in cultured chick ventricular myocytes. Shimizu, T., Kinugawa, K., Yao, A., Sugishita, Y., Sugishita, K., Harada, K., Matsui, H., Kohmoto, O., Serizawa, T., Takahashi, T. Cardiovasc. Res. (1999) [Pubmed]
  19. Thyroid hormones regulate DNA-synthesis and cell-cycle proteins by activation of PKCalpha and p42/44 MAPK in chick embryo hepatocytes. Alisi, A., Spagnuolo, S., Napoletano, S., Spaziani, A., Leoni, S. J. Cell. Physiol. (2004) [Pubmed]
  20. Evidence against the regulation of caldesmon inhibitory activity by p42/p44erk mitogen-activated protein kinase in vitro and demonstration of another caldesmon kinase in intact gizzard smooth muscle. Krymsky, M.A., Chibalina, M.V., Shirinsky, V.P., Marston, S.B., Vorotnikov, A.V. FEBS Lett. (1999) [Pubmed]
  21. p38 mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock. Hayashi, Y., Sanada, K., Hirota, T., Shimizu, F., Fukada, Y. J. Biol. Chem. (2003) [Pubmed]
  22. Wnt-5a is involved in TGF-beta3-stimulated chondrogenic differentiation of chick wing bud mesenchymal cells. Jin, E.J., Park, J.H., Lee, S.Y., Chun, J.S., Bang, O.S., Kang, S.S. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  23. Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways. Tang, F., Kalil, K. J. Neurosci. (2005) [Pubmed]
  24. Two signal transduction pathways involved in the catecholaminergic differentiation of avian neural crest-derived cells in vitro. Wu, X., Howard, M.J. Mol. Cell. Neurosci. (2001) [Pubmed]
  25. Opposing actions of TGFbeta and MAP kinase signaling in undifferentiated hen granulosa cells. Woods, D.C., Haugen, M.J., Johnson, A.L. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  26. Molecular mechanisms involved in LH release by the ovine pituitary cells. Yang, D., Caraty, A., Dupont, J. Domest. Anim. Endocrinol. (2005) [Pubmed]
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