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Gene Review

LEPR  -  leptin receptor

Canis lupus familiaris

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High impact information on LEPR

  • We previously reported that rat brain microvessels, which constitute the blood-brain barrier, contain large amounts of messenger RNA encoding a short form of the leptin receptor (ObRa), suggesting that this site may be important for receptor-mediated transport of leptin into the brain [1].
  • Furthermore, immunocytochemistry demonstrated that the long-form leptin receptor protein (ObRb) is present in human coronary endothelium [2].
  • RT-PCR analysis revealed that the leptin receptor gene is expressed in canine coronary arteries and human coronary endothelium [2].


  1. Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells. Hileman, S.M., Tornøe, J., Flier, J.S., Bjørbaek, C. Endocrinology (2000) [Pubmed]
  2. Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction. Knudson, J.D., Dincer, U.D., Zhang, C., Swafford, A.N., Koshida, R., Picchi, A., Focardi, M., Dick, G.M., Tune, J.D. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
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