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Gene Review

LEPR  -  leptin receptor

Gallus gallus

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Disease relevance of LEPR


High impact information on LEPR

  • However, comparison between the predicted protein sequences has shown a tight conservation of most previously characterized LEPR motifs and essential tyrosine residues [3].
  • These changes were accompanied by a significant down-regulation of leptin receptor gene expression, however SREBP-1, the main transcription factor of lipogenic genes, remained unchanged [4].
  • Finally, the ability of insulin and leptin to regulate chicken leptin receptor gene expression suggests a direct role of leptin in the control of hepatic metabolism [5].
  • The present study was aimed at detecting chicken leptin receptor (cOb-R) expression in isolated chicken islets of Langerhans and to examine the direct effect of leptin on insulin secretion after stimulation by acetylcholine (1 micro M) + glucose (14 mM) from isolated perfused chicken pancreas [6].
  • The recombinant chicken leptin markedly inhibits food intake as reported in mammals, suggesting the presence of an hypothalamic leptin receptor [7].

Biological context of LEPR


Anatomical context of LEPR


Other interactions of LEPR

  • Furthermore, acquisition of the anorectic effect of leptin is likely to be associated with greater expression of the leptin receptor and NPY mRNAs than to changes in blood levels of leptin [2].

Analytical, diagnostic and therapeutic context of LEPR


  1. Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor. Niv-Spector, L., Raver, N., Friedman-Einat, M., Grosclaude, J., Gussakovsky, E.E., Livnah, O., Gertler, A. Biochem. J. (2005) [Pubmed]
  2. Peripheral leptin effect on food intake in young chickens is influenced by age and strain. Cassy, S., Picard, M., Crochet, S., Derouet, M., Keisler, D.H., Taouis, M. Domest. Anim. Endocrinol. (2004) [Pubmed]
  3. Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene. Horev, G., Einat, P., Aharoni, T., Eshdat, Y., Friedman-Einat, M. Mol. Cell. Endocrinol. (2000) [Pubmed]
  4. Potential role of leptin in increase of fatty acid synthase gene expression in chicken liver. Dridi, S., Buyse, J., Decuypere, E., Taouis, M. Domest. Anim. Endocrinol. (2005) [Pubmed]
  5. Leptin and insulin downregulate leptin receptor gene expression in chicken-derived leghorn male hepatoma cells. Cassy, S., Derouet, M., Crochet, S., Dridi, S., Taouis, M. Poult. Sci. (2003) [Pubmed]
  6. Leptin fully suppresses acetylcholine-induced insulin secretion and is reversed by tolbutamide in isolated perfused chicken pancreas. Benomar, Y., Rideau, N., Crochet, S., Derouet, M., Taouis, M. Horm. Metab. Res. (2003) [Pubmed]
  7. Chicken leptin: properties and actions. Taouis, M., Dridi, S., Cassy, S., Benomar, Y., Raver, N., Rideau, N., Picard, M., Williams, J., Gertler, A. Domest. Anim. Endocrinol. (2001) [Pubmed]
  8. Leptin receptor in the chicken ovary: potential involvement in ovarian dysfunction of ad libitum-fed broiler breeder hens. Cassy, S., Metayer, S., Crochet, S., Rideau, N., Collin, A., Tesseraud, S. Reprod. Biol. Endocrinol. (2004) [Pubmed]
  9. Identification of sequence tagged sites in the Asian and African elephant. Burk, N.E., Messer, L.A., Ernst, C.W., Rothschild, M.F. Anim. Biotechnol. (1998) [Pubmed]
  10. Structure and tissue distribution of chicken leptin receptor (cOb-R) mRNA. Ohkubo, T., Tanaka, M., Nakashima, K. Biochim. Biophys. Acta (2000) [Pubmed]
  11. Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus). Paczoska-Eliasiewicz, H.E., Gertler, A., Proszkowiec, M., Proudman, J., Hrabia, A., Sechman, A., Mika, M., Jacek, T., Cassy, S., Raver, N., Rzasa, J. Reproduction (2003) [Pubmed]
  12. Molecular cloning and expression of the turkey leptin receptor gene. Richards, M.P., Poch, S.M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2003) [Pubmed]
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