High impact information on LEPR

• In conclusion, leptin improved the ability of the oocyte to sustain embryonic development and had long-term effects on blastocyst apoptosis and transcript abundance of LEPR, STAT3, and apoptosis-associated genes [1].
• Considerable leptin receptor expression was observed in the milk-producing epithelial cells, which is the same cell type that produces most of the udder leptin [2].
• The T945M polymorphism may have induced a structural change in the intracellular domain of the LEPR, which may have influenced the signal transduction pathway [3].
• A missense mutation in the bovine leptin receptor gene is associated with leptin concentrations during late pregnancy [3].
• The leptin receptor (LEPR) gene consists of 20 exons divided over 1.75 Mb [3].

Biological context of LEPR

• Short communication: Tissue distribution of leptin and leptin receptor mRNA in the bovine [4].
• We report here evidence of leptin receptor gene expression in central and peripheral tissues of the bovine by reverse transcription and polymerase chain reaction analysis [4].
• Insulin alone down-regulated the leptin signaling pathway, JAK-2 association with ObR decreased at all time-points, and JAK-2 phosphorylation decreased similarly [5].

Anatomical context of LEPR

• In addition, we determined that MAC-T cells and isolated bovine mammary epithelial cells express the long form of leptin receptor (Ob-Rb) mRNA [6].
• The mRNA for the short form of the leptin receptor, Ob-Ra, was detectable in the liver, adrenal cortex, spleen, pituitary, and brain stem, but not in the other tissues surveyed [4].
• The aim of this study was to determine whether the expression of the obese (Ob) gene and lipoprotein lipase (LPL) gene in fat tissues and expression of the long isoform leptin receptor (Ob-Rb) gene in the hypothalamus were different between these two cattle breeds [7].
• Expression and localisation of leptin and leptin receptor in the mammary gland of the dry and lactating non-pregnant cow [8].
• Expression of leptin receptor and suppressor of cytokine signaling-3 genes in adenohypophysis of normal-fed and fasted cows [9].

Associations of LEPR with chemical compounds

• Pretreatment with leptin followed by insulin time-course showed marked up-regulation of the early leptin signaling pathway, JAK-2 association with the ObR being increased by insulin while JAK-2 tyrosine phosphorylation was also increased [5].

Other interactions of LEPR

• Comparing mRNA levels of genes encoding leptin, leptin receptor, and lipoprotein lipase between dairy and beef cattle [7].

References