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Gene Review

Lepr  -  leptin receptor

Rattus norvegicus

Synonyms: Fa, LEP-R, Leptin receptor, OB receptor, OB-R, ...
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Disease relevance of Lepr


Psychiatry related information on Lepr


High impact information on Lepr


Chemical compound and disease context of Lepr


Biological context of Lepr


Anatomical context of Lepr

  • Treatment with anti-OB-R for 3 weeks more than halved the content of bone marrow leukemic cells with a concomitant, substantial decrease in angiogenesis [14].
  • Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus [15].
  • In +/+ but not in fa/fa rats, plasma catecholamine levels rose, and both P-STAT3 and P-CREB increased in adipose tissue, suggesting that both direct and indirect (hypothalamic) leptin receptor-mediated actions of hyperleptinemia are involved in depletion of adipocyte fat [19].
  • Double in situ hybridization histochemistry revealed that, in contrast to the situation in the arcuate nucleus, NPY and leptin receptor mRNA-expressing neurons were not colocalized in the DMH [20].
  • Leptin receptor mRNA levels in the uterus are also regulated with an increase about 2.7-fold during this same period, whereas there is no change in other tissues examined [21].

Associations of Lepr with chemical compounds


Physical interactions of Lepr


Enzymatic interactions of Lepr

  • Phosphorylated leptin receptor and phosphorylated signal transducer and activator of transcription-3 (p-STAT3) remained elevated in association with a sustained elevation in DNA-binding activity of STAT3 in the hypothalamus throughout 16-d period of leptin infusion [28].

Regulatory relationships of Lepr


Other interactions of Lepr


Analytical, diagnostic and therapeutic context of Lepr


  1. Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats. Holm, A.M., Johansen, P.B., Ahnfelt-Rønne, I., Rømer, J. Eur. J. Endocrinol. (2004) [Pubmed]
  2. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Morton, G.J., Niswender, K.D., Rhodes, C.J., Myers, M.G., Blevins, J.E., Baskin, D.G., Schwartz, M.W. Endocrinology (2003) [Pubmed]
  3. High birth weight increases mammary tumorigenesis in rats. de Assis, S., Khan, G., Hilakivi-Clarke, L. Int. J. Cancer (2006) [Pubmed]
  4. Fatty acids inhibit leptin signalling in BRIN-BD11 insulinoma cells. Briscoe, C.P., Hanif, S., Arch, J.R., Tadayyon, M. J. Mol. Endocrinol. (2001) [Pubmed]
  5. Effects of leptin and cholecystokinin in rats with a null mutation of the leptin receptor Lepr(fak). Wildman, H.F., Chua, S., Leibel, R.L., Smith, G.P. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2000) [Pubmed]
  6. Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats. Jang, M.H., Shin, M.C., Kim, K.H., Cho, S.Y., Bahn, G.H., Kim, E.H., Kim, C.J. Brain Res. (2003) [Pubmed]
  7. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Cheung, C.C., Clifton, D.K., Steiner, R.A. Endocrinology (1997) [Pubmed]
  8. Leptin receptor missense mutation in the fatty Zucker rat. Phillips, M.S., Liu, Q., Hammond, H.A., Dugan, V., Hey, P.J., Caskey, C.J., Hess, J.F. Nat. Genet. (1996) [Pubmed]
  9. Direct effects of leptin on brown and white adipose tissue. Siegrist-Kaiser, C.A., Pauli, V., Juge-Aubry, C.E., Boss, O., Pernin, A., Chin, W.W., Cusin, I., Rohner-Jeanrenaud, F., Burger, A.G., Zapf, J., Meier, C.A. J. Clin. Invest. (1997) [Pubmed]
  10. Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Zhou, Y.T., Shimabukuro, M., Wang, M.Y., Lee, Y., Higa, M., Milburn, J.L., Newgard, C.B., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. Fever responses of Zucker rats with and without fatty mutation of the leptin receptor. Ivanov, A.I., Romanovsky, A.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  12. Different responsiveness in body weight and hepatic 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 mrna to 11beta-HSD inhibition by glycyrrhetinic acid treatment in obese and lean zucker rats. Li, R.S., Nakagawa, Y., Nakanishi, T., Fujisawa, Y., Ohzeki, T. Metab. Clin. Exp. (2004) [Pubmed]
  13. Serotonergic dorsal raphe neurons from obese zucker rats are hyperexcitable. Ohliger-Frerking, P., Horwitz, B.A., Horowitz, J.M. Neuroscience (2003) [Pubmed]
  14. Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Iversen, P.O., Drevon, C.A., Reseland, J.E. Blood (2002) [Pubmed]
  15. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. Hâkansson, M.L., Brown, H., Ghilardi, N., Skoda, R.C., Meister, B. J. Neurosci. (1998) [Pubmed]
  16. Characterization of bone structure in leptin receptor-deficient Zucker (fa/fa) rats. Tamasi, J.A., Arey, B.J., Bertolini, D.R., Feyen, J.H. J. Bone Miner. Res. (2003) [Pubmed]
  17. Circulating hormones and hypothalamic energy balance: regulatory gene expression in the Lou/C and Wistar rats. Mitchell, S.E., Nogueiras, R., Rance, K., Rayner, D.V., Wood, S., Dieguez, C., Williams, L.M. J. Endocrinol. (2006) [Pubmed]
  18. Young Adult-Specific Hyperphagia in Diabetic Goto-Kakizaki Rats is Associated with Leptin Resistance and Elevation of Neuropeptide Y mRNA in the Arcuate Nucleus. Maekawa, F., Fujiwara, K., Kohno, D., Kuramochi, M., Kurita, H., Yada, T. J. Neuroendocrinol. (2006) [Pubmed]
  19. Combined Leptin Actions on Adipose Tissue and Hypothalamus Are Required to Deplete Adipocyte Fat in Lean Rats: IMPLICATIONS FOR OBESITY TREATMENT. Park, B.H., Wang, M.Y., Lee, Y., Yu, X., Ravazzola, M., Orci, L., Unger, R.H. J. Biol. Chem. (2006) [Pubmed]
  20. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Bi, S., Robinson, B.M., Moran, T.H. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  21. Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Chien, E.K., Hara, M., Rouard, M., Yano, H., Phillippe, M., Polonsky, K.S., Bell, G.I. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  22. Leptin and Its Receptor Are Controlled by 17{beta}-Estradiol in Peripheral Tissues of Ovariectomized Rats. Alonso, A., Fernández, R., Moreno, M., Ordóñez, P., Díaz, F., González, C. Exp. Biol. Med. (Maywood) (2007) [Pubmed]
  23. Leptin receptor-deficient obese Zucker rats reduce their food intake in response to a systemic supply of calories from glucose. Gilbert, M., Magnan, C., Turban, S., André, J., Guerre-Millo, M. Diabetes (2003) [Pubmed]
  24. Effect of nicotine on the expression of leptin and forebrain leptin receptors in the rat. Li, M.D., Kane, J.K. Brain Res. (2003) [Pubmed]
  25. Differential regulation of leptin receptor but not orexin in the hypothalamus of the lactating rat. Brogan, R.S., Grove, K.L., Smith, M.S. J. Neuroendocrinol. (2000) [Pubmed]
  26. Expression of the long (OB-RB) and short (OB-RA) forms of the leptin receptor throughout the oestrous cycle in the mature rat ovary. Duggal, P.S., Weitsman, S.R., Magoffin, D.A., Norman, R.J. Reproduction (2002) [Pubmed]
  27. Plasma leptin-binding activity and hypothalamic leptin receptor expression during pregnancy and lactation in the rat. Seeber, R.M., Smith, J.T., Waddell, B.J. Biol. Reprod. (2002) [Pubmed]
  28. Leptin signaling in the hypothalamus during chronic central leptin infusion. Pal, R., Sahu, A. Endocrinology (2003) [Pubmed]
  29. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. Horvath, T.L., Diano, S., van den Pol, A.N. J. Neurosci. (1999) [Pubmed]
  30. Divergent effects of intracerebroventricular and peripheral leptin administration on feeding and hypothalamic neuropeptide Y in lean and obese (fa/fa) Zucker rats. Dryden, S., King, P., Pickavance, L., Doyle, P., Williams, G. Clin. Sci. (1999) [Pubmed]
  31. Differential expression of mRNA for leptin receptor isoforms in the rat brain. Guan, X.M., Hess, J.F., Yu, H., Hey, P.J., van der Ploeg, L.H. Mol. Cell. Endocrinol. (1997) [Pubmed]
  32. Leptin and connective tissue growth factor in advanced glycation end-product-induced effects in NRK-49F cells. Lee, C.I., Guh, J.Y., Chen, H.C., Lin, K.H., Yang, Y.L., Hung, W.C., Lai, Y.H., Chuang, L.Y. J. Cell. Biochem. (2004) [Pubmed]
  33. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Baskin, D.G., Breininger, J.F., Schwartz, M.W. Diabetes (1999) [Pubmed]
  34. Regulation of cholecystokinin-mediated amylase secretion by leptin in rat pancreatic acinar tumor cell line AR42J. Harris, D.M., Flannigan, K.L., Go, V.L., Wu, S.V. Pancreas (1999) [Pubmed]
  35. Secretion of soluble leptin receptors by exocrine and endocrine cells of the gastric mucosa. Cammisotto, P.G., Gingras, D., Renaud, C., Levy, E., Bendayan, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  36. Effects of acetate and butyrate on the expression of leptin and short-form leptin receptor in bovine and rat anterior pituitary cells. Yonekura, S., Senoo, T., Kobayashi, Y., Yonezawa, T., Katoh, K., Obara, Y. Gen. Comp. Endocrinol. (2003) [Pubmed]
  37. Leptin receptor expression in the basolateral nucleus of amygdala of conditioned taste aversion rats. Han, Z., Yan, J.Q., Luo, G.G., Liu, Y., Wang, Y.L. World J. Gastroenterol. (2003) [Pubmed]
  38. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Fortuño, A., Rodríguez, A., Gómez-Ambrosi, J., Muñiz, P., Salvador, J., Díez, J., Frühbeck, G. Endocrinology (2002) [Pubmed]
  39. Electrophysiological characterization of left ventricular myocytes from obese Sprague-Dawley rat. Ricci, E., Smallwood, S., Chouabe, C., Mertani, H.C., Raccurt, M., Morel, G., Bonvallet, R. Obesity (Silver Spring, Md.) (2006) [Pubmed]
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