High impact information on Sox100B

• We show that this process is largely dependent on Sox9 function as Wnt-mediated neural crest induction is inhibited in the context of Sox9-depleted embryos [1].
• Early requirement of the transcriptional activator Sox9 for neural crest specification in Xenopus [1].
• Expression of a construct in which Sox9 DNA-binding domain (HMG box) is fused to the repressor domain of Drosophila engrailed blocked neural crest formation, thereby mimicking the phenotype of Sox9-depleted embryos [1].
• Finally, using a hormone-inducible inhibitory mutant of Sox9, lacking the transactivation domain, we show that Sox9 function is required for neural crest specification but not for its subsequent migration [1].
• During embryogenesis in Drosophila, Sox100B is expressed in two rows of large intestinal cells, in midgut basophilic cells, in the Malpighian tubules and at the posterior cap of gonadal mesoderm [2].

Biological context of Sox100B

• Male-specific somatic gonadal precursors (msSGPs) contribute only to the testis and express a Drosophila homolog of Sox9 (Sox100B), a gene essential for testis formation in humans [3].

Anatomical context of Sox100B

• Here, we describe experiments that further investigate Sox9 function during neural crest development [1].

References