High impact information on cv-2

• Cv-2 is expressed in the chick embryo in a number of tissues at sites at which elevated BMP signalling is required [1].
• Furthermore, we find that increased expression of Cv-2 causes premature onset of trunk neural crest cell migration in the chick embryo, indicative of Cv-2 acting to promote BMP activity at an endogenous site of expression [1].
• A vertebrate crossveinless 2 homologue modulates BMP activity and neural crest cell migration [1].
• These features strongly suggest that Crossveinless 2 acts extracelluarly or in the secretory pathway to directly potentiate Dpp or Gbb signaling [2].
• The Crossveinless 2 protein contains a putative signal or transmembrane sequence, and a partial Von Willebrand Factor D domain similar to those known to regulate the formation of intramolecular and intermolecular bonds [2].

Other interactions of cv-2

• However, this requirement can be overridden by co-misexpression of the BMP agonist Cv-2, indicating the presence of as yet unknown cues; we discuss possible candidates [3].

References