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Gene Review

BMPER  -  BMP binding endothelial regulator

Homo sapiens

Synonyms: BMP-binding endothelial regulator protein, Bone morphogenetic protein-binding endothelial cell precursor-derived regulator, CRIM3, CV-2, CV2, ...
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Disease relevance of BMPER

  • Studying novel molecules such as BMPER that modulate BMP activity and that are expressed in vascular cells will help to understand vasculogenetic signaling and may open up new therapeutic avenues in vascular disease [1].
  • Limbic encephalitis (LE) is often associated with lung, thymic, or testicular tumours and antibodies to Hu, CV2, or Ma2 (Ta) antigens [2].
  • We report on a case of CV2 paraneoplastic syndrome with obsessive-compulsive behavior preceding the motor manifestations of chorea with associated leukoencephalopathy on MRI [3].

High impact information on BMPER

  • Serum from 10/10 idiopathic and 12/14 paraneoplastic OMS patients showed no specific immunoreactivity on rat or human brainstem or cerebellum, lacked specific antineuronal antibodies (Hu, Yo, Ri, Tr, glutamic acid decarboxylase, amphiphysin or CV2) and did not contain antibodies to voltage-gated calcium channels [4].
  • CV2 antigen expression by the oligodendrocytes of the cerebellum, brainstem, spinal cord, and optic chiasm correlated with the clinical syndrome observed in our patient [5].
  • Interestingly, hCV-2 messenger RNA is expressed at high levels in human primary chondrocytes, whereas expression in primary human osteoblasts is low [6].
  • RESULTS: The availability, mean transit time and normalised variance (CV2) obtained for labelled red blood cells, sucrose and water were similar before and after melphalan dosing and with the two methods of calculation but varied between the patients [7].
  • Cervical N13 potential in response to the median nerve stimulation can be recorded either from upper (Cv2) or lower (Cv6) neck with almost equal amplitudes and latencies [8].

Biological context of BMPER

  • Predicted area under curve (AUC), mean transit time (MTT) and normalized variance (CV2) data have been compared for parent compound and generated metabolite following an impulse input into the liver [9].

Associations of BMPER with chemical compounds

  • The normalized variances (CV2) of the markers were of the following order: sucrose (2.18) > water (1.58) > EB (0.68), indicating that some disequilibrium occurs during the capillary exchange of water and sucrose [10].

Analytical, diagnostic and therapeutic context of BMPER

  • CONCLUSIONS: The vascular space is not well-stirred but characterized by a CV2 similar that reported previously for in situ rat hind limb and rat liver perfusions [7].


  1. Bone morphogenetic proteins and vascular differentiation: BMPing up vasculogenesis. Moser, M., Patterson, C. Thromb. Haemost. (2005) [Pubmed]
  2. Potassium channel antibodies in two patients with reversible limbic encephalitis. Buckley, C., Oger, J., Clover, L., Tüzün, E., Carpenter, K., Jackson, M., Vincent, A. Ann. Neurol. (2001) [Pubmed]
  3. Paraneoplastic chorea with leukoencephalopathy presenting with obsessive-compulsive and behavioral disorder. Muehlschlegel, S., Okun, M.S., Foote, K.D., Coco, D., Yachnis, A.T., Fernandez, H.H. Mov. Disord. (2005) [Pubmed]
  4. Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus. Bataller, L., Graus, F., Saiz, A., Vilchez, J.J. Brain (2001) [Pubmed]
  5. Paraneoplastic cerebellar syndrome and optic neuritis with anti-CV2 antibodies: clinical response to excision of the primary tumor. de la Sayette, V., Bertran, F., Honnorat, J., Schaeffer, S., Iglesias, S., Defer, G. Arch. Neurol. (1998) [Pubmed]
  6. Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Binnerts, M.E., Wen, X., Canté-Barrett, K., Bright, J., Chen, H.T., Asundi, V., Sattari, P., Tang, T., Boyle, B., Funk, W., Rupp, F. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  7. Relative dispersion of intravascular transit times during isolated human limb perfusions for recurrent melanoma. Roberts, M.S., Wu, Z.Y., Rivory, L.P., Smithers, B.M., Egerton, W.S., Weiss, M. British journal of clinical pharmacology. (1997) [Pubmed]
  8. Dissociation between upper and lower neck N13 potentials following paired median nerve stimuli. Araki, A., Yamada, T., Ito, T., Urushibara, N., Kohira, R., Hsu, S.P., Yeh, M. Electroencephalography and clinical neurophysiology. (1997) [Pubmed]
  9. Metabolite mean transit times in the liver as predicted by various models of hepatic elimination. Mellick, G.D., Anissimov, Y.G., Bracken, A.J., Roberts, M.S. Journal of pharmacokinetics and biopharmaceutics. (1997) [Pubmed]
  10. Physiological pharmacokinetics of solutes in the isolated perfused rat hindlimb: characterization of the physiology with changing perfusate flow, protein content, and temperature using statistical moment analysis. Wu, Z.Y., Rivory, L.P., Roberts, M.S. Journal of pharmacokinetics and biopharmaceutics. (1993) [Pubmed]
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