High impact information on Fbp2

• This stage-specific alteration in localization requires mitosis-specific phosphorylation of the T19 Cdc2 site in Cut3 [1].
• A 2.2-kb region including the Fbp2 locus was sequenced for 10 chromosomes from a D. melanogaster sample from West Africa and for the related species D. simulans [2].
• Methionine is involved in 46% of amino acid replacements when Fbp2 DNA sequences are compared between D. melanogaster and D. pseudoobscura [3].
• In D. melanogaster, there is one methionine in ADH, while there are 51 (20% of all amino acids) in FBP2 [3].
• Methionine accumulation does not affect conserved residues of the ADH-ADHr-FBP2 multigene family [3].

Biological context of Fbp2

• The P6 gene showed little linkage disequilibrium with the In(2L)t inversion, although it is located within this inversion [4].
• This suggests that the inversion and the P6 locus have extensively exchanged genetic information through either double crossover or gene conversion [4].
• Molecular variation of Adh and P6 genes in an African population of Drosophila melanogaster and its relation to chromosomal inversions [4].

Anatomical context of Fbp2

• P6 is also homologous to the 25-kd protein from the fat body of Sarcophaga peregrina, whose sequence we have reexamined [5].

Associations of Fbp2 with chemical compounds

• Ecdysterone increases the level of the P1 transcript, but not of the P6 transcript, in ecdysterone-deficient ecd1 larvae [6].

Other interactions of Fbp2

• We present evidence that the Drosophila ADH is phylogenetically more closely related to P6, another highly expressed protein from the fat body of Drosophila, than it is to the short-chain dehydrogenases [5].
• Polymorphic loci appear to fall into two distinct groups: weakly polymorphic, including larval protein 6, 7, 8, 10 and 13 and esterase-1 and -6; and highly polymorphic, including esterase-5, Xdh and possibly Ao [7].

References