The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Phlebovirus

  • The role of the variable portion of the noncoding regions (NCRs) of the three Bunyaviridae RNA segments (L, M, S) in transcription, replication, and packaging was studied using the recently developed plasmid-driven RNA polymerase I minigenome system for Uukuniemi (UUK) virus, genus Phlebovirus (11), as a model [1].
  • Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) was markedly inhibitory in vitro to Adames and Balliet strains of Punta Toro virus (PTV), a Phlebovirus related to Rift Valley fever and sandfly fever viruses [2].
  • Inspection of the sequences in the primers on nairovirus, bunyavirus and phlebovirus mRNAs suggests that in some cases polymerase slippage occurs shortly after initiation, resulting in a partial reiteration of the 5'-terminal nucleotides of the viral RNA [3].
  • The phlebovirus glycoprotein cleavage site was similar to a region in the MStV and RStV proteins suggesting that the tenuivirus pvc2 may be processed analogous to the phlebovirus glycoproteins [4].
  • Here we have studied the intracellular transport and targeting to the GC of G1 and G2 of Uukuniemi virus, a member of the Phlebovirus genus, and report on their expression from cloned cDNAs either together or separately by using a T7 RNA polymerase-driven vaccinia virus expression system [5].

High impact information on Phlebovirus

  • Moreover, we showed that N(TOS), the N protein of the related Toscana phlebovirus, interacts with itself and forms heterodimers with N(RVF), suggesting that the dimeric form of N may be a conserved feature in phlebovirus RNPs [6].
  • In vitro and in vivo Phlebovirus inhibition by ribavirin [2].
  • Some BEL-like elements have captured an envelope gene, probably from other retroelements in some cases but from a phlebovirus in one case [7].
  • In this study we have constructed a series of full length or truncated mutants of the G2 glycoprotein of Punta Toro virus (PTV), a member of the Phlebovirus genus of the Bunyaviridae, and investigated their transport properties [8].
  • Molecular analyses indicate that Turlock virus (TUR, Turlock serogroup) and Boraceia virus (BOR, Anopheles B serogroup) have virion RNA species and polypeptides comparable in size to those of members of the Bunyavirus genus and unlike those of members of the newly defined Phlebovirus, Nairovirus, or Uukuvirus genera (Bunyaviridae) [9].

Chemical compound and disease context of Phlebovirus

  • Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections [10].
  • Selectivity indices of human recombinant interferon-alpha (IFN alpha) (Roferon and Introna), iota-, kappa- and lambda- carrageenans, fucoidan and 6-azauridine were much higher than that of ribavirin, the only antiviral substance which has been previously investigated for its inhibitory effects on Phlebovirus infections [11].

Gene context of Phlebovirus


  1. Functional analysis of the noncoding regions of the Uukuniemi virus (Bunyaviridae) RNA segments. Flick, K., Katz, A., Overby, A., Feldmann, H., Pettersson, R.F., Flick, R. J. Virol. (2004) [Pubmed]
  2. In vitro and in vivo Phlebovirus inhibition by ribavirin. Sidwell, R.W., Huffman, J.H., Barnett, B.B., Pifat, D.Y. Antimicrob. Agents Chemother. (1988) [Pubmed]
  3. Non-viral sequences at the 5' ends of Dugbe nairovirus S mRNAs. Jin, H., Elliott, R.M. J. Gen. Virol. (1993) [Pubmed]
  4. Maize stripe tenuivirus RNA2 transcripts in plant and insect hosts and analysis of pvc2, a protein similar to the Phlebovirus virion membrane glycoproteins. Estabrook, E.M., Suyenaga, K., Tsai, J.H., Falk, B.W. Virus Genes (1996) [Pubmed]
  5. The membrane glycoprotein G1 of Uukuniemi virus contains a signal for localization to the Golgi complex. Melin, L., Persson, R., Andersson, A., Bergström, A., Rönnholm, R., Pettersson, R.F. Virus Res. (1995) [Pubmed]
  6. The N terminus of Rift Valley fever virus nucleoprotein is essential for dimerization. Le May, N., Gauliard, N., Billecocq, A., Bouloy, M. J. Virol. (2005) [Pubmed]
  7. New BEL-like LTR-retrotransposons in Fugu rubripes, Caenorhabditis elegans, and Drosophila melanogaster. Frame, I.G., Cutfield, J.F., Poulter, R.T. Gene (2001) [Pubmed]
  8. Golgi complex localization of the Punta Toro virus G2 protein requires its association with the G1 protein. Chen, S.Y., Matsuoka, Y., Compans, R.W. Virology (1991) [Pubmed]
  9. Radioimmune assays and molecular studies that place Anopheles B and Turlock serogroup viruses in the Bunyavirus genus (Bunyaviridae). Klimas, R.A., Ushijima, H., Clerx-Van Haaster, C.M., Bishop, D.H. Am. J. Trop. Med. Hyg. (1981) [Pubmed]
  10. Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections. Sidwell, R.W., Huffman, J.H., Barnard, D.L., Pifat, D.Y. Antiviral Res. (1988) [Pubmed]
  11. Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds. Crance, J.M., Gratier, D., Guimet, J., Jouan, A. Res. Virol. (1997) [Pubmed]
  12. Enzyme polymorphism and genetic variability of laboratory populations of Phlebotomus papatasi, P. bergeroti, P. langeroni, and P. perniciosus. Kassem, H.A., Fryauff, D.J., Hanafi, H.A. Journal of the Egyptian Society of Parasitology. (1999) [Pubmed]
WikiGenes - Universities