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Gene Review:

bic - bicaudal

Drosophila melanogaster

Synonyms: 107/12, 5A, BcDNA.GM05329, BcDNA:GM05329, Bic, ...

Markesich, D.C. et al., Baens, M. et al., Rittenhouse, K.R. et al., Scharf, M.E. et al., Mohler, J. et al.

Scharf, Wu-Scharf, Pittendrigh, Bennett,

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High impact information on bic

bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery* [1].
The lethal phenotype of Enhancer of Bicaudal, E(Bic), a mutation hypothesized to affect the bicaudal locus, is also completely rescued by the beta NAC locus [1].
Unlike other bicaudal mutants, oskar mRNA is localized correctly to the posterior pole of the oocyte at stage 10 [2].
We previously isolated a cDNA fragment homologous to the Drosophila Bicaudal-D gene (Bic-D) using a hybridization selection procedure with cosmids derived from the short arm of human chromosome 12 [3].
The two transcription/translation factors showed significant homology to the bicaudal and bric-a-brac developmental genes of Drosophila [4].

Biological context of bic

Genomic DNA encoding beta NAC completely rescues the bicaudal phenotype [1].

Anatomical context of bic

The bicaudal phenotype is also germ-line dependent for bullwinkle [2].
Bicaudal mutations of Drosophila melanogaster: alteration of blastoderm cell fate [5].

References

bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery*. Markesich, D.C., Gajewski, K.M., Nazimiec, M.E., Beckingham, K. Development (2000) [Pubmed]
Mutations in the Drosophila gene bullwinkle cause the formation of abnormal eggshell structures and bicaudal embryos. Rittenhouse, K.R., Berg, C.A. Development (1995) [Pubmed]
A human homologue (BICD1) of the Drosophila bicaudal-D gene. Baens, M., Marynen, P. Genomics (1997) [Pubmed]
Caste- and development-associated gene expression in a lower termite. Scharf, M.E., Wu-Scharf, D., Pittendrigh, B.R., Bennett, G.W. Genome Biol. (2003) [Pubmed]
Bicaudal mutations of Drosophila melanogaster: alteration of blastoderm cell fate. Mohler, J., Wieschaus, E.F. Cold Spring Harb. Symp. Quant. Biol. (1985) [Pubmed]

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