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Gene Review

sra  -  sarah

Drosophila melanogaster

Synonyms: 89B, 89B11, CG6072, Dmel\CG6072, Protein nebula, ...
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High impact information on sra

  • Eggs laid by sarah mutant females arrest in anaphase of meiosis I and fail to fully polyadenylate and translate bicoid mRNA [1].
  • Furthermore, sarah mutant eggs show elevated cyclin B levels, indicating a failure to inactivate M-phase promoting factor (MPF) [1].
  • Taken together, these results demonstrate that calcium signaling is involved in Drosophila egg activation and suggest a molecular mechanism for the sarah phenotype [1].
  • The calcineurin regulator sra plays an essential role in female meiosis in Drosophila [2].
  • Here, we show that the Drosophila MCIP sarah (sra) is essential for meiotic progression in oocytes [2].

Biological context of sra

  • This phenotype was due to loss of function of sra specifically in the female germline [2].
  • Eggs from sra null mothers are arrested at anaphase of meiosis I [2].
  • Taken together, these results indicate that the expression level of sra is critical for ovulation and female courtship behavior, including their postmating changes [3].


  1. The Drosophila calcipressin sarah is required for several aspects of egg activation. Horner, V.L., Czank, A., Jang, J.K., Singh, N., Williams, B.C., Puro, J., Kubli, E., Hanes, S.D., McKim, K.S., Wolfner, M.F., Goldberg, M.L. Curr. Biol. (2006) [Pubmed]
  2. The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. Takeo, S., Tsuda, M., Akahori, S., Matsuo, T., Aigaki, T. Curr. Biol. (2006) [Pubmed]
  3. Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship behavior in Drosophila melanogaster. Ejima, A., Tsuda, M., Takeo, S., Ishii, K., Matsuo, T., Aigaki, T. Genetics (2004) [Pubmed]
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