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Gene Review

Rcan2  -  regulator of calcineurin 2

Mus musculus

Synonyms: Calcineurin inhibitory protein ZAKI-4, Calcipressin-2, Csp2, Down syndrome candidate region 1-like protein 1, Dscr1l1, ...
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High impact information on Dscr1l1

  • Here we disrupted the mcip1 and mcip2 genes in the mouse and provide multiple lines of evidence that endogenous MCIP functions as a calcineurin facilitator in vivo [1].
  • The effect of thyroid hormone on the expression of ZAKI-4 isoforms in mouse brain and heart was also studied [2].
  • The gene was mapped on chromosome 17qC, syntenic to human chromosome 6 where the human ZAKI-4 gene is located [2].
  • ZAKI-4 alpha mRNA was lower in the cerebral cortex of hypothyroid mice [2].
  • Injection of L-T(3) caused an increase in ZAKI-4 beta mRNA in heart; however, expression of neither ZAKI-4 alpha nor beta mRNA was influenced by thyroid status in other tissues [2].

Anatomical context of Dscr1l1


Analytical, diagnostic and therapeutic context of Dscr1l1

  • METHODS: Total RNA extracted from mouse cerebellum was used to clone ZAKI-4 alpha and beta cDNAs by RT-PCR followed by rapid amplification of cDNA ends [2].


  1. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Sanna, B., Brandt, E.B., Kaiser, R.A., Pfluger, P., Witt, S.A., Kimball, T.R., van Rooij, E., De Windt, L.J., Rothenberg, M.E., Tschop, M.H., Benoit, S.C., Molkentin, J.D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Genomic organization of mouse ZAKI-4 gene that encodes ZAKI-4 alpha and beta isoforms, endogenous calcineurin inhibitors, and changes in the expression of these isoforms by thyroid hormone in adult mouse brain and heart. Mizuno, Y., Kanou, Y., Rogatcheva, M., Imai, T., Refetoff, S., Seo, H., Murata, Y. Eur. J. Endocrinol. (2004) [Pubmed]
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