Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

RA25 - Rheumatoid arthritis QTL 25

Homo sapiens

Nassar, P.M. et al., Ruggiero, A.C. et al., Borissevitch, I.E. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RA25

Antioxidant effect of dipyridamole (DIP) and its derivative RA 25 upon lipid peroxidation and hemolysis in red blood cells [1].

High impact information on RA25

The antioxidant effect of DIP was considerably higher than that of RA25 [1].
For isolated ghost membranes, the apparent IC50 (the drug concentration that produces 50% inhibition of lipid peroxidation) in cumene hydroperoxide-induced peroxidation was 25 microM, while the maximum protective effect of RA-25 was around 30% in the drug concentration range of 50-100 microM [1].
Binding and localization of the vasodilator and antitumor drug coactivator dipyridamole (DIP) and one of its derivatives, RA25, to phospholipid vesicles of DMPC (dimyristoylphosphatidylcholine) and DPPC (dipalmitoylphosphatidylcholine) was studied using fluorescence spectroscopy as well as quenching of fluorescence [2].
In the case of RA25, the drug is in the outer part of the head group interface being much exposed to the aqueous phase and being significantly less accessible to the membrane nitroxide quenchers [2].
The analysis of NMR, optical absorption and fluorescence data indicates that the depth of localization of the drugs in the micelles from the surface decreased in the order DIP > RA14 > RA47 > RA25 [3].

References

Antioxidant effect of dipyridamole (DIP) and its derivative RA 25 upon lipid peroxidation and hemolysis in red blood cells. Ruggiero, A.C., Nepomuceno, M.F., Jacob, R.F., Dorta, D.J., Tabak, M. Physiological chemistry and physics and medical NMR. (2000) [Pubmed]
Binding of dipyridamole to phospholipid vesicles: a fluorescence study. Nassar, P.M., Almeida, L.E., Tabak, M. Biochim. Biophys. Acta (1997) [Pubmed]
Binding and location of dipyridamole derivatives in micelles: the role of drug molecular structure and charge. Borissevitch, I.E., Borges, C.P., Borissevitch, G.P., Yushmanov, V.E., Louro, S.R., Tabak, M. Z. Naturforsch., C, J. Biosci. (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.