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Gene Review:

Thym1 - Thymus enlargement QTL 1

Rattus norvegicus

Sharma, N. et al., Toyota, M. et al., Ye, C. et al., Hall, C.E. et al., Murakumo, Y. et al.

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Disease relevance of Thym1

Rats injected with 19-nor-DOCA and given water to drink showed enhanced growth and developed thymus enlargement and displayed hypokalemia and a reduction in both serum renin activity and corticosterone concentration [1].
The thymoma prone BUF/Mna (B) rat is a useful model for studying the genes responsible for thymus enlargement during the stage of young growth [2].

High impact information on Thym1

By two RDA series with the restriction enzymes BglII and BamHI, respectively, 28 polymorphic markers were isolated, and 8 of them were shown to be linked to Ten1, and one to Ten2 [3].
One of the 8 markers linked to Ten1 demonstrated no recombination in 18 rats with high thymus ratios [3].
Linkage studies between Ten-1 and microsatellite markers in backcross rats of (WKY/NCrj x BUF/Mna)F1 x BUF/Mna have led to the localization of Ten-1 in chromosome 1 [4].
By analyses of MAPMAKER/EXP and MAPMAKER/QTL, Ten-1 was mapped at 4.6 cM proximal from IGF2 locus on chromosome 1 and Tsu-1 at 4.0 cM proximal from CAT locus on chromosome 3, respectively [2].
A locus, Ten-1, which contributes to thymus enlargement in back-cross (BC) rats between the B and WKY/NCrj (W) strains, was mapped on chromosome 1 [2].

Biological context of Thym1

To further characterize the precise position of Ten1, 34 and 37 microsatellite markers, that have a polymorphism between the B and WYK (W) and between the B and MITE (M) strains, were used for linkage analysis of thymus enlargement in 105 (WBF1 x B) blackcross (BC) and 78 (B x BMF1) BC rats, respectively [5].
This is known to be controlled by single major and minor genes, Ten1 and Ten2, on Chromosomes (Chrs) 1 and 13, respectively, both of which have dose effects on the normal WKY/Ncj (WKY) allele [3].
Linkages with thymus enlargement were found in genotypes of seven markers, BSIS, LSN, MYL2, IGF2, PBPC2, D1Mgh11, and D1MIt6, by chi2-test and Student's t-test, which confirmed the presence of the genetic locus associated with thymus enlargement, Ten-1, in this region [2].

Other interactions of Thym1

Two polymeric autosomal loci, Ten1 and Ten2, regulate thymus enlargement in BUF/Mna (B) rats [5].

References

Influence of 19-nor-deoxycorticosterone on blood pressure, saline consumption, and serum electrolytes, corticosterone, and renin activity. Hall, C.E., Gomez-Sanchez, C.E., Holland, O.B., Nasseth, D. Endocrinology (1979) [Pubmed]
Genetic mapping of genes regulating the thymus size in back-cross rats between the laboratory BUF/Mna strain and the MITE strain derived from the wild rat, Rattus norvegicus. Sharma, N., Ohyabu, A., Murakumo, Y., Takahashi, M., Saito, M., Amo, H., Murayama, S., Ohno, K., Oda, S., Matsuyama, M. Pathol. Int. (1997) [Pubmed]
Generation of polymorphic markers tightly linked to the thymus enlargement loci by phenotype-directed representational difference analysis. Toyota, M., Ushijima, T., Suzui, M., Murakumo, Y., Imai, K., Sugimura, T., Matsuyama, M. Mamm. Genome (1998) [Pubmed]
Chromosomal mapping of genetic locus associated with thymus-size enlargement in BUF/Mna rats. Murakumo, Y., Takahashi, M., Arakawa, A., Saito, M., Amo, H., Katoh, H., Matsuyama, M. Jpn. J. Cancer Res. (1993) [Pubmed]
Fine mapping of thymus enlargement gene 1 (Ten1) in BUF/Mna rats. Ye, C., Murakumo, Y., Higo, K., Matsuyama, M. Pathol. Int. (2000) [Pubmed]

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