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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nutrition Policy

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Disease relevance of Nutrition Policy


High impact information on Nutrition Policy

  • METHODS: To test this hypothesis, we assessed the effects of breakfast cereals fortified with three levels of folic acid, and also containing the recommended dietary allowances of vitamins B6 and B12, in a randomized, double-blind, placebo-controlled, crossover trial in 75 men and women with coronary artery disease [6].
  • Representational difference analysis (RDA) cloning has identified transcriptional intermediary factor 1 beta (TIF1beta) as a gene inducibly expressed early during myeloid differentiation of the promyelocytic cell lines HL-60 and U937 [7].
  • Recommendations for vitamin C intake are under revision by the Food and Nutrition Board of the National Academy of Sciences. Since 1989 when the last recommended dietary allowance (RDA) of 60 mg was published, extensive biochemical, molecular, epidemiologic, and clinical data have become available [8].
  • CONCLUSIONS--Increasing daily calcium intake from 80% of the recommended daily allowance to 110% via supplementation with calcium citrate malate resulted in significant increases in total body and spinal bone density in adolescent girls [9].
  • The basal diet, a standard commercial mouse chow, contains more vitamin A than the National Research Council's recommended dietary allowance for normal rodents and supports normal growth, reproduction, and longevity of normal mice [10].

Chemical compound and disease context of Nutrition Policy


Biological context of Nutrition Policy


Anatomical context of Nutrition Policy


Associations of Nutrition Policy with chemical compounds

  • Based on an EAR of 100 mg/d of vitamin C, the RDA is proposed to be 120 mg/d. If the EAR cannot be determined, an adequate intake (AI) amount is recommended instead of an RDA [8].
  • A recent study shows that a significant proportion of the population is consuming less than 66% of the recommended dietary allowance for calcium, iron, magnesium, and vitamin B6 [25].
  • Based on these data and Institute of Medicine criteria, the current RDA of 60 mg daily should be increased to 200 mg daily, which can be obtained from fruits and vegetables [16].
  • Women taking estrogen replacement should be provided the RDA for calcium of 800 mg/day at a minimum [26].
  • In both sexes, increasing retinol became negatively associated with skeletal health at intakes not far beyond the recommended daily allowance (RDA), intakes reached predominately by supplement users [27].

Gene context of Nutrition Policy

  • In an attempt to gain insight into the molecular mechanisms involved in interleukin-9 (IL-9) activities, representational difference analysis (RDA) was used to identify messages that are induced by IL-9 in a murine T-helper-cell clone [28].
  • Genes up regulated by EWS/FLI1 but not by full-length FLI1 were identified by representational difference analysis (RDA) [29].
  • Furthermore, using cDNA representational difference analysis (RDA), we show that these cellular effects are associated with marked induction of the gene NDRG1, which was previously identified as a target of transcriptional repression by N-myc and induction by the tumor suppressor protein p53 [30].
  • The objectives of this study were to investigate the effect of the MTHFR 677 T allele on folate status variables in Mexican women (n = 43; 18-45 y) and to assess the adequacy of the 1998 folate U.S. Recommended Dietary Allowance (RDA), 400 micro g/d as dietary folate equivalents (DFE) [31].
  • Six percent of 595 cDNAs isolated by cDNA RDA were mec-3-dependent [32].

Analytical, diagnostic and therapeutic context of Nutrition Policy

  • Daily for 14 d, elemental zinc (20 mg) and multivitamins (vitamins A and D, thiamine, riboflavin, and nicotinamide) plus calcium were given at twice the US recommended dietary allowance to the zinc group (n=28), and multivitamins plus calcium were given to the control group (n=28) [33].
  • To determine whether this new RDA for smokers is sufficient to reduce the risk of low serum ascorbic acid (AA) concentrations (LoC) to the same concentration as nonsmokers, we analyzed the dietary intakes and serum concentrations of AA in 11,582 adult respondents in the National Health and Nutrition Examination Survey (1976-1980) [34].
  • We report a diet that provides a stable intake of vitamin K1 equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography [35].
  • To explore the molecular basis of the tumor suppressor activity of the Sai1 region, we analyzed the RNO5q23-q36 region with several genes and microsatellite markers that could be assigned to the region, as well as with new markers derived by representational difference analysis (RDA) or by microdissection [36].
  • To identify differentially expressed genes in c-Myc transgenic mouse liver, we compared the virtues of probing commercially available cDNA arrays with either radiolabeled cDNA pools or radiolabeled difference products (DP2) derived from RDA using c-Myc transgenic and normal mouse liver [37].


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  2. Parameters related to 25-OH-D levels in a population-based study of women. Sowers, M.R., Wallace, R.B., Hollis, B.W., Lemke, J.H. Am. J. Clin. Nutr. (1986) [Pubmed]
  3. Lowering dietary protein to U.S. Recommended dietary allowance levels reduces urinary calcium excretion and bone resorption in young women. Ince, B.A., Anderson, E.J., Neer, R.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  4. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Carr, A.C., Frei, B. Am. J. Clin. Nutr. (1999) [Pubmed]
  5. Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. Shi-wen, X., Pennington, D., Holmes, A., Leask, A., Bradham, D., Beauchamp, J.R., Fonseca, C., du Bois, R.M., Martin, G.R., Black, C.M., Abraham, D.J. Exp. Cell Res. (2000) [Pubmed]
  6. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. Malinow, M.R., Duell, P.B., Hess, D.L., Anderson, P.H., Kruger, W.D., Phillipson, B.E., Gluckman, R.A., Block, P.C., Upson, B.M. N. Engl. J. Med. (1998) [Pubmed]
  7. TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937. Rooney, J.W., Calame, K.L. Genes Dev. (2001) [Pubmed]
  8. Criteria and recommendations for vitamin C intake. Levine, M., Rumsey, S.C., Daruwala, R., Park, J.B., Wang, Y. JAMA (1999) [Pubmed]
  9. Calcium supplementation and bone mineral density in adolescent girls. Lloyd, T., Andon, M.B., Rollings, N., Martel, J.K., Landis, J.R., Demers, L.M., Eggli, D.F., Kieselhorst, K., Kulin, H.E. JAMA (1993) [Pubmed]
  10. Prophylactic and therapeutic actions of supplemental beta-carotene in mice inoculated with C3HBA adenocarcinoma cells: lack of therapeutic action of supplemental ascorbic acid. Rettura, G., Stratford, F., Levenson, S.M., Seifter, E. J. Natl. Cancer Inst. (1982) [Pubmed]
  11. Nutrient intake and congenital heart defects in maternal phenylketonuria. Michals-Matalon, K., Platt, L.D., Acosta P, P., Azen, C., Walla, C.A. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  12. Regulation of keratin 19 gene expression by estrogen in human breast cancer cells and identification of the estrogen responsive gene region. Choi, I., Gudas, L.J., Katzenellenbogen, B.S. Mol. Cell. Endocrinol. (2000) [Pubmed]
  13. Effects of deferoxamine and a diet deficient in vitamin E on isoelectric electroencephalographic responses associated with ischemia by the four vessel occlusion method. Lin, X.M., Waller, S.B., Dietz, N.J. Life Sci. (1995) [Pubmed]
  14. The epidemiology of dental caries and periodontal disease. Sheiham, A. Journal of clinical periodontology. (1979) [Pubmed]
  15. Effect of vitamin A in enteral formulae for burned guinea-pigs. Kuroiwa, K., Trocki, O., Alexander, J.W., Tchervenkov, J., Inoue, S., Nelson, J.L. Burns : journal of the International Society for Burn Injuries. (1990) [Pubmed]
  16. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R.W., Washko, P.W., Dhariwal, K.R., Park, J.B., Lazarev, A., Graumlich, J.F., King, J., Cantilena, L.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  17. Identification of a novel gene NCRMS on chromosome 12q21 with differential expression between rhabdomyosarcoma subtypes. Chan, A.S., Thorner, P.S., Squire, J.A., Zielenska, M. Oncogene (2002) [Pubmed]
  18. Intake of major nutrients by women in the Maternal Phenylketonuria (MPKU) Study and effects on plasma phenylalanine concentrations. Acosta, P.B., Matalon, K., Castiglioni, L., Rohr, F.J., Wenz, E., Austin, V., Azen, C. Am. J. Clin. Nutr. (2001) [Pubmed]
  19. Vitamin B6 nutriture during pregnancy and lactation. I. Vitamin B6 intake, levels of the vitamin in biological fluids, and condition of the infant at birth. Roepke, J.L., Kirksey, A. Am. J. Clin. Nutr. (1979) [Pubmed]
  20. Vitamin B12 deficiency in the elderly. Baik, H.W., Russell, R.M. Annu. Rev. Nutr. (1999) [Pubmed]
  21. Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome. Ellis, J., Folkers, K., Watanabe, T., Kaji, M., Saji, S., Caldwell, J.W., Temple, C.A., Wood, F.S. Am. J. Clin. Nutr. (1979) [Pubmed]
  22. Exercise and protein intake effects on urinary 3-methylhistidine excretion. Hickson, J.F., Hinkelmann, K. Am. J. Clin. Nutr. (1985) [Pubmed]
  23. Biotin in human milk: methods, location, and chemical form. Mock, D.M., Mock, N.I., Langbehn, S.E. J. Nutr. (1992) [Pubmed]
  24. Isolation of ethanol-induced genes in pancreatic beta-cells by representational difference analysis (RDA). Shin, J.S., Kwon, Y.S., Lee, J.J., Kim, C.W. Exp. Mol. Med. (2004) [Pubmed]
  25. Nutritional consequences of reducing sodium intake. Engstrom, A.M., Tobelmann, R.C. Ann. Intern. Med. (1983) [Pubmed]
  26. The role of calcium in osteoporosis. Arnaud, C.D., Sanchez, S.D. Annu. Rev. Nutr. (1990) [Pubmed]
  27. Retinol intake and bone mineral density in the elderly: the Rancho Bernardo Study. Promislow, J.H., Goodman-Gruen, D., Slymen, D.J., Barrett-Connor, E. J. Bone Miner. Res. (2002) [Pubmed]
  28. Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones. Louahed, J., Grasso, L., De Smet, C., Van Roost, E., Wildmann, C., Nicolaides, N.C., Levitt, R.C., Renauld, J.C. Blood (1999) [Pubmed]
  29. EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Thompson, A.D., Braun, B.S., Arvand, A., Stewart, S.D., May, W.A., Chen, E., Korenberg, J., Denny, C. Oncogene (1996) [Pubmed]
  30. The leukemogenic transcription factor E2a-Pbx1 induces expression of the putative N-myc and p53 target gene NDRG1 in Ba/F3 cells. Rutherford, M.N., Bayly, G.R., Matthews, B.P., Okuda, T., Dinjens, W.M., Kondoh, H., LeBrun, D.P. Leukemia (2001) [Pubmed]
  31. Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women. Guinotte, C.L., Burns, M.G., Axume, J.A., Hata, H., Urrutia, T.F., Alamilla, A., McCabe, D., Singgih, A., Cogger, E.A., Caudill, M.A. J. Nutr. (2003) [Pubmed]
  32. MTD-1, a touch-cell-specific membrane protein with a subtle effect on touch sensitivity. Zhang, Y., Chalfie, M. Mech. Dev. (2002) [Pubmed]
  33. Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis. Rahman, M.J., Sarker, P., Roy, S.K., Ahmad, S.M., Chisti, J., Azim, T., Mathan, M., Sack, D., Andersson, J., Raqib, R. Am. J. Clin. Nutr. (2005) [Pubmed]
  34. Ascorbic acid requirements for smokers: analysis of a population survey. Schectman, G., Byrd, J.C., Hoffmann, R. Am. J. Clin. Nutr. (1991) [Pubmed]
  35. Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1 content. Booth, S.L., Charnley, J.M., Sadowski, J.A., Saltzman, E., Bovill, E.G., Cushman, M. Thromb. Haemost. (1997) [Pubmed]
  36. A dual-color FISH framework map for the characterization of the Sai1 tumor suppression region on rat chromosome 5. Helou, K., Lü, X.C., Montelius-Alatalo, K., Ståhl, F., Klinga-Levan, K., Levan, G., Röhme, D. Genes Chromosomes Cancer (2000) [Pubmed]
  37. A strategy to identify differentially expressed genes using representational difference analysis and cDNA arrays. Kim, S., Zeller, K., Dang, C.V., Sandgren, E.P., Lee, L.A. Anal. Biochem. (2001) [Pubmed]
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