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Gene Review

CAV2  -  caveolin 2

Canis lupus familiaris

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Disease relevance of CAV2

  • Because canine adenovirus 2 (CAV2) is licensed for use as a live vaccine for dogs and has an excellent efficacy and safety record, we used this virus as an expression vector for the RVG [1].
  • Recently, all major companies that make canine vaccines for the U.S. market have completed their own studies; published data show a 3 years or longer minimum DOI for the canine core products, canine distemper virus (CDV), canine parvovirus type 2 (CPV-2), and canine adenovirus-2 (CAV-2) [2].

High impact information on CAV2

  • The recombinant CAV2-RV G produces virus titers similar to those produced by wild-type CAV2, indicating that the RVG gene does not affect virus replication [1].


  1. A single immunization with a recombinant canine adenovirus expressing the rabies virus G protein confers protective immunity against rabies in mice. Li, J., Faber, M., Papaneri, A., Faber, M.L., McGettigan, J.P., Schnell, M.J., Dietzschold, B. Virology (2006) [Pubmed]
  2. Duration of immunity for canine and feline vaccines: A review. Schultz, R.D. Vet. Microbiol. (2006) [Pubmed]
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