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Gene Review

Cav2  -  caveolin 2

Mus musculus

Synonyms: AI447843, Caveolin-2
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Disease relevance of Cav2

  • C57BL/6 mice were infected with recombinant human caveolin-1 and caveolin-2 adenoviruses [1].

High impact information on Cav2


Biological context of Cav2


Anatomical context of Cav2


Associations of Cav2 with chemical compounds


Physical interactions of Cav2


Other interactions of Cav2

  • Three SH2 domain-containing proteins, c-Src, Nck, and Ras-GAP, were found to associate with Cav-2 in a phosphorylation-dependent manner [9].
  • Recombinant expression of caveolin-2 under the same conditions failed to drive the formation of vesicles, while caveolin-3 expression yielded caveolae-sized vesicles [12].

Analytical, diagnostic and therapeutic context of Cav2

  • Both immunoblot analysis and immunohistochemistry dramatically show that Cav-1 and Cav-2 expression is downregulated to almost undetectable levels in the lungs of post-MI rats [13].


  1. Hepatic overexpression of caveolins increases bile salt secretion in mice. Moreno, M., Molina, H., Amigo, L., Zanlungo, S., Arrese, M., Rigotti, A., Miquel, J.F. Hepatology (2003) [Pubmed]
  2. Caveolin-1 is not essential for biosynthetic apical membrane transport. Manninen, A., Verkade, P., Le Lay, S., Torkko, J., Kasper, M., Füllekrug, J., Simons, K. Mol. Cell. Biol. (2005) [Pubmed]
  3. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Razani, B., Wang, X.B., Engelman, J.A., Battista, M., Lagaud, G., Zhang, X.L., Kneitz, B., Hou, H., Christ, G.J., Edelmann, W., Lisanti, M.P. Mol. Cell. Biol. (2002) [Pubmed]
  4. Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. Lee, H., Park, D.S., Wang, X.B., Scherer, P.E., Schwartz, P.E., Lisanti, M.P. J. Biol. Chem. (2002) [Pubmed]
  5. Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice. Kaja, S., Van de Ven, R.C., Ferrari, M.D., Frants, R.R., Van den Maagdenberg, A.M., Plomp, J.J. J. Neurophysiol. (2006) [Pubmed]
  6. Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation. Schubert, W., Sotgia, F., Cohen, A.W., Capozza, F., Bonuccelli, G., Bruno, C., Minetti, C., Bonilla, E., Dimauro, S., Lisanti, M.P. Am. J. Pathol. (2007) [Pubmed]
  7. Localization of group V phospholipase A2 in caveolin-enriched granules in activated P388D1 macrophage-like cells. Balboa, M.A., Shirai, Y., Gaietta, G., Ellisman, M.H., Balsinde, J., Dennis, E.A. J. Biol. Chem. (2003) [Pubmed]
  8. Caveolin-1 and caveolin-2 expression in mouse macrophages. High density lipoprotein 3-stimulated secretion and a lack of significant subcellular co-localization. Gargalovic, P., Dory, L. J. Biol. Chem. (2001) [Pubmed]
  9. Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). Wang, X.B., Lee, H., Capozza, F., Marmon, S., Sotgia, F., Brooks, J.W., Campos-Gonzalez, R., Lisanti, M.P. Biochemistry (2004) [Pubmed]
  10. Evidence for heme oxygenase-1 association with caveolin-1 and -2 in mouse mesangial cells. Jung, N.H., Kim, H.P., Kim, B.R., Cha, S.H., Kim, G.A., Ha, H., Na, Y.E., Cha, Y.N. IUBMB Life (2003) [Pubmed]
  11. Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells. Capozza, F., Cohen, A.W., Cheung, M.W., Sotgia, F., Schubert, W., Battista, M., Lee, H., Frank, P.G., Lisanti, M.P. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  12. Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes. Li, S., Galbiati, F., Volonte, D., Sargiacomo, M., Engelman, J.A., Das, K., Scherer, P.E., Lisanti, M.P. FEBS Lett. (1998) [Pubmed]
  13. Lung remodeling and pulmonary hypertension after myocardial infarction: pathogenic role of reduced caveolin expression. Jasmin, J.F., Mercier, I., Hnasko, R., Cheung, M.W., Tanowitz, H.B., Dupuis, J., Lisanti, M.P. Cardiovasc. Res. (2004) [Pubmed]
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