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Gene Review:

CAV2 - caveolin 2

Bos taurus

Boyd, N. et al., Pöyry, T. et al.

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Disease relevance of CAV2

In the capsid coding region five clusters were seen: PVs, CAV21 and CAV24 formed one cluster (PV-like); ENV70 formed a cluster of its own; all CBVs, CAV9, EV11, EV12 and SVDV formed the third cluster (CBV-like); CAV16, CAV2 and ENV71 belonged to the fourth cluster (CAV16-like) and BEVs formed their own cluster (BEV-like) [1].

High impact information on CAV2

Here, we show that BAECs express caveolin-2, which localizes in caveolae with caveolin-1 [2].
Normally, cells that express caveolin-1 also express caveolin-2, but this has not been demonstrated in bovine aortic endothelial cells (BAECs) [2].
Therefore, the interaction of caveolin-2 with caveolin-1 could play an important role in caveolae biogenesis and shear stimulated mechano-signal transduction [2].
We used differential gradient centrifugations and immunoprecipitation to show that bovine caveolin-2 and caveolin-1 form a hetero-oligomer in plasma membrane caveolae [2].

Anatomical context of CAV2

Bovine caveolin-2 cloning and effects of shear stress on its localization in bovine aortic endothelial cells [2].

References

Genetic and phylogenetic clustering of enteroviruses. Pöyry, T., Kinnunen, L., Hyypiä, T., Brown, B., Horsnell, C., Hovi, T., Stanway, G. J. Gen. Virol. (1996) [Pubmed]
Bovine caveolin-2 cloning and effects of shear stress on its localization in bovine aortic endothelial cells. Boyd, N., Park, H., Sun, W.P., Coleman, S., Cherukuri, R., Jo, H. Endothelium (2004) [Pubmed]

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